Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination

Mieszko Olczak; Magdalena Kwiatkowska; Justyna Niderla-Bielińska; Dominik Chutorański; Sylwia Tarka; Teresa Wierzba-Bobrowicz

doi:10.5114/fn.2018.76613

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2018
vol. 56

Send email

Copy url:

abstract:

Original paper

Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination

Mieszko Olczak

,

Magdalena Kwiatkowska

,

Justyna Niderla-Bielińska

,

Dominik Chutorański

,

Sylwia Tarka

,

Teresa Wierzba-Bobrowicz

Folia Neuropathol 2018; 56 (2): 97-103

DOI: https://doi.org/10.5114/fn.2018.76613

Online publish date: 2018/06/28

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Olczak M, Kwiatkowska M, Niderla-Bielińska J, Chutorański D, Tarka S, Wierzba-Bobrowicz T. Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination. Folia Neuropathologica. 2018;56(2):97-103. doi:10.5114/fn.2018.76613.

APA

Olczak, M., Kwiatkowska, M., Niderla-Bielińska, J., Chutorański, D., Tarka, S.,  & Wierzba-Bobrowicz, T. (2018). Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination. Folia Neuropathologica, 56(2), 97-103. https://doi.org/10.5114/fn.2018.76613

Chicago

Olczak, Mieszko, Magdalena Kwiatkowska, Justyna Niderla-Bielińska, Dominik Chutorański, Sylwia Tarka,  and Teresa Wierzba-Bobrowicz. 2018. "Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination". Folia Neuropathologica 56 (2): 97-103. doi:10.5114/fn.2018.76613.

Harvard

Olczak, M., Kwiatkowska, M., Niderla-Bielińska, J., Chutorański, D., Tarka, S.,  and Wierzba-Bobrowicz, T. (2018). Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination. Folia Neuropathologica, 56(2), pp.97-103. https://doi.org/10.5114/fn.2018.76613

MLA

Olczak, Mieszko et al. "Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination." Folia Neuropathologica, vol. 56, no. 2, 2018, pp. 97-103. doi:10.5114/fn.2018.76613.

Vancouver

Olczak M, Kwiatkowska M, Niderla-Bielińska J, Chutorański D, Tarka S, Wierzba-Bobrowicz T. Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination. Folia Neuropathologica. 2018;56(2):97-103. doi:10.5114/fn.2018.76613.

PlumX metrics:

The release of brain-originated peptides such as tau protein (MAPT), S-100β, neurofilament light chain (NFL), and glial fibrillary acidic protein (GFAP) into the cerebrospinal fluid (CSF) has been positively correlated with head injuries in clinical and basic research. In this study, we wanted to examine if selected CSF biomarkers (GFAP, NFL, and myelin basic protein – MBP) of head injury may be useful in post-mortem examination and diagnosis of forensic cases. The study was carried out using cases of head injury and cases of sudden death (cardiopulmonary failure, no injuries of the head as control group) provided by forensic pathologists at the Department of Forensic Medicine, Medical University of Warsaw. Cerebrospinal fluid was collected within 24 h after death using suboccipital puncture. The concentration of these peptides was compared using an enzyme-linked immunosorbent assay (ELISA). Brain specimens (frontal cortex) were collected during forensic autopsies. Sections were stained immunohistochemically against GFAP, MBP, NF, and amyloid-β precursor protein (APP). As a result we documented that elevated levels of CSF, GFAP, MBP, and NFL should be considered a marker for severe and moderate traumatic brain injury. Elevated levels of those peptides combined with a negative APP staining point to their role as markers of head trauma with a shorter time span than APP (manner of minutes).

keywords:

Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination

Mieszko Olczak , Magdalena Kwiatkowska , Justyna Niderla-Bielińska , Dominik Chutorański , Sylwia Tarka , Teresa Wierzba-Bobrowicz

TBI markers, post-mortem examination, neurofilaments, glial fibrillary acidic protein, myelin basic protein

Mieszko Olczak

,

Magdalena Kwiatkowska

,

Justyna Niderla-Bielińska

,

Dominik Chutorański

,

Sylwia Tarka

,

Teresa Wierzba-Bobrowicz