Californium <i>versus</i> cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute

Ernestas Janulionis; Konstantinas Povilas Valuckas; Sarune Liukpetryte; Vitalija Samerdokiene; Vydmantas Atkocius

doi:10.5114/jcb.2015.55117

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

**Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute**

Ernestas Janulionis

,

Konstantinas Povilas Valuckas

,

Sarune Liukpetryte

,

Vitalija Samerdokiene

,

Vydmantas Atkocius

J Contemp Brachytherapy 2015; 7, 5: 346-351

DOI: https://doi.org/10.5114/jcb.2015.55117

Online publish date: 2015/10/19

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AMA

Janulionis E, Valuckas K, Liukpetryte S, Samerdokiene V, Atkocius V. Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute. Journal of Contemporary Brachytherapy. 2015;7(5):346-351. doi:10.5114/jcb.2015.55117.

APA

Janulionis, E., Valuckas, K., Liukpetryte, S., Samerdokiene, V.,  & Atkocius, V. (2015). Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute. Journal of Contemporary Brachytherapy, 7(5), 346-351. https://doi.org/10.5114/jcb.2015.55117

Chicago

Janulionis, Ernestas, Konstantinas Povilas Valuckas, Sarune Liukpetryte, Vitalija Samerdokiene,  and Vydmantas Atkocius. 2015. "Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute". Journal of Contemporary Brachytherapy 7 (5): 346-351. doi:10.5114/jcb.2015.55117.

Harvard

Janulionis, E., Valuckas, K., Liukpetryte, S., Samerdokiene, V.,  and Atkocius, V. (2015). Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute. Journal of Contemporary Brachytherapy, 7(5), pp.346-351. https://doi.org/10.5114/jcb.2015.55117

MLA

Janulionis, Ernestas et al. "Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute." Journal of Contemporary Brachytherapy, vol. 7, no. 5, 2015, pp. 346-351. doi:10.5114/jcb.2015.55117.

Vancouver

Janulionis E, Valuckas K, Liukpetryte S, Samerdokiene V, Atkocius V. Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute. Journal of Contemporary Brachytherapy. 2015;7(5):346-351. doi:10.5114/jcb.2015.55117.

Purpose: The purpose of this paper was to observe and compare long-term curative effects and complications of FIGO stage IIB cervical cancer patients (n = 232) treated with high-dose-rate (HDR) californium (²⁵²Cf) neutron or cobalt (⁶⁰Co) photon intracavitary brachytherapy (ICBT) combined with external-beam radiotherapy (EBRT).

Material and methods: The EBRT dose to the small pelvis was 50 Gy in both groups. The brachytherapy component of ²⁵²Cf or ⁶⁰Co was added in the 3^rd week of EBRT, 5 fractions were performed once per week resulting in a total ICBT dose of 40 Gy/Gy_eq (point A).

Results: Overall survival (OS) at 5, 10 and 15 years was 63.6%, 50.4% and 38.8% in the ²⁵²Cf group and 62.2%, 50.5%, 39.9%, in the ⁶⁰Co group, respectively (p = 0.74). The percentage of tumour recurrence was statistically significantly lower in the ²⁵²Cf group with 7.4 % versus 17.1% in the ⁶⁰Co group (p = 0.02). Second primary cancers have developed similarly 9.1% and 8.1% cases for ²⁵²Cf and ⁶⁰Co groups, respectively.

Conclusions: Our long-term retrospective study comparing ²⁵²Cf and ⁶⁰Co isotopes with brachytherapy in combined treatment of FIGO IIB stage cervix carcinoma patients shows, that overall survival in the both groups are similar. However, the recurrence of tumour was significantly lower in the

keywords:

Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute

Ernestas Janulionis , Konstantinas Povilas Valuckas , Sarune Liukpetryte , Vitalija Samerdokiene , Vydmantas Atkocius

brachytherapy, 252Cf, cervical cancer, 60Co, neutron brachytherapy

**Californium versus cobalt brachytherapy combined with external-beam radiotherapy for IIB stage cervical cancer: long-term experience of a single institute**

Ernestas Janulionis

,

Konstantinas Povilas Valuckas

,

Sarune Liukpetryte

,

Vitalija Samerdokiene

,

Vydmantas Atkocius

brachytherapy, ²⁵²Cf, cervical cancer, ⁶⁰Co, neutron brachytherapy