eISSN: 1896-9151
ISSN: 1734-1922
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2/2008
vol. 4
 
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Case report
Transient thyrotoxicosis following prolonged use of gonadotropin-releasing hormone agonist in women with endometriosis – a case report

Akira Nakashima
,
Koji Nakagawa
,
Shirei Ohgi
,
Takashi Horikawa
,
Toshiharu Kamura
,
Hidekazu Saito

Arch Med Sci 2008; 4, 2: 200–203
Online publish date: 2008/06/27
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This paper reports two cases showing transient thyrotoxicosis caused by prolonged use of gonadotropin-releasing hormone (GnRH) agonist. Case 1, a 31-year-old woman, was administered GnRH-agonist (leuprorelin acetate) for treatment of endometriosis. After four months she showed thyroid dysfunction. Case 2, a 43-year-old woman, who was previously diagnosed with chronic thyroiditis, was treated with GnRH-agonist (nafarelin acetate) for her endometriosis. Five months later, her thyroid functions worsened. After discontinuation of the GnRH-agonist, thyroid function of both cases recovered. In selected patients, who are on GnRH-agonist, attention to thyroid function is important.
keywords:

GnRH-agonist, endometriosis, thyroid grand, thyroiditis
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