Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

Blanka Hermann; Michal Woznica; Wojciech Kloc; Piotr Borkowski; Witold Libionka; Ewa Izycka-Swieszewska

doi:10.5114/fn.2017.70488

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2017
vol. 55

Send email

Copy url:

abstract:

Case report

Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

Blanka Hermann

,

Michal Woznica

,

Wojciech Kloc

,

Piotr Borkowski

,

Witold Libionka

,

Ewa Izycka-Swieszewska

Folia Neuropathol 2017; 55 (3): 227-234

DOI: https://doi.org/10.5114/fn.2017.70488

Online publish date: 2017/09/30

View full text Get citation

PlumX metrics:

We present a case of a rare neoplasm in a 77-year-old woman with previous oncological history, who developed a rapid onset of cerebellar symptoms. The neuroimaging detected a posterior fossa tumor suspected of meningioma which was completely resected soon after. Histologically the neoplasm had two components with different immunophenotype. One constituent was lobular, composed of monotonous mitotically active round cells with a predominant neuronal profile. The second, astrocytic component contained lipomatous cells intermixed with larger gemistocytic astrocytes. Fields of geographic necrosis as well as multifocal microvascular proliferation were observed. The Ki67 proliferation index was 12%. After two years of follow-up the patient remains free of symptoms and radiologic recurrence.

The presented case of cerebellar liponeurocytoma is unusual in terms of its atypical histological features and prominent astrocytic component. The authors propose that the term ‘lipomatous glioneuronal tumor’ seems to be more appropriate for this type of lesion, considering its histologic spectrum and possible extracerebellar location.

keywords:

Cerebellar liponeurocytoma with atypical histological features – a rare example of a glioneuronal tumor

Blanka Hermann , Michal Woznica , Wojciech Kloc , Piotr Borkowski , Witold Libionka , Ewa Izycka-Swieszewska

cerebellar liponeurocytoma, lipidized tumor, glioneuronal tumor

Blanka Hermann

,

Michal Woznica

,

Wojciech Kloc

,

Piotr Borkowski

,

Witold Libionka

,

Ewa Izycka-Swieszewska