Clinical immunology<br>Gene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression

Robert Słotwiński; Aleksandra Dąbrowska; Gustaw Lech; Maciej Słodkowski; Sylwia M. Słotwińska

doi:10.5114/ceji.2014.47736

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Clinical immunology
Gene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression

Robert Słotwiński

,

Aleksandra Dąbrowska

,

Gustaw Lech

,

Maciej Słodkowski

,

Sylwia M. Słotwińska

(Centr Eur J Immunol 2014; 39 (4): 498-507)

DOI: https://doi.org/10.5114/ceji.2014.47736

Online publish date: 2014/12/15

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AMA

Słotwiński R, Dąbrowska A, Lech G, Słodkowski M, Słotwińska S. Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression. Central European Journal of Immunology. 2014;39(4):498-507. doi:10.5114/ceji.2014.47736.

APA

Słotwiński, R., Dąbrowska, A., Lech, G., Słodkowski, M.,  & Słotwińska, S. (2014). Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression. Central European Journal of Immunology, 39(4), 498-507. https://doi.org/10.5114/ceji.2014.47736

Chicago

Słotwiński, Robert, Aleksandra Dąbrowska, Gustaw Lech, Maciej Słodkowski,  and Sylwia M. Słotwińska. 2014. "Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression". Central European Journal of Immunology 39 (4): 498-507. doi:10.5114/ceji.2014.47736.

Harvard

Słotwiński, R., Dąbrowska, A., Lech, G., Słodkowski, M.,  and Słotwińska, S. (2014). Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression. Central European Journal of Immunology, 39(4), pp.498-507. https://doi.org/10.5114/ceji.2014.47736

MLA

Słotwiński, Robert et al. "Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression." Central European Journal of Immunology, vol. 39, no. 4, 2014, pp. 498-507. doi:10.5114/ceji.2014.47736.

Vancouver

Słotwiński R, Dąbrowska A, Lech G, Słodkowski M, Słotwińska S. Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression. Central European Journal of Immunology. 2014;39(4):498-507. doi:10.5114/ceji.2014.47736.

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The study was carried out to investigate changes in gene expression of innate antibacterial signaling pathways in patients with pancreatic cancer. Expression of the following genes was measured in peripheral blood leukocytes of 55 patients with pancreatic adenocarcinoma using real-time polymerase chain reaction (RT-PCR): TLR4, NOD1, MyD88, TRAF6 and HMGB1. The levels of expression of TLR4, NOD1 and TRAF6 genes were significantly elevated (p = 0.007; p = 0.001 and p = 0.01, respectively), while MyD88 expression was markedly reduced (p = 0.0002), as compared to controls. Expression of TLR4 and NOD1 exceeded the normal level more than 3.5-fold and there was a significant correlation found between the expression of these genes (r = 0.558, p < 0.001). TLR4, NOD1 and MyD88 genes were expressed at a similar level both before and after surgery. No significant changes in the expression of HMGB1 gene were observed. The results of the study clearly indicate abnormal expression of genes belonging to innate antibacterial signaling pathways in peripheral blood leukocytes of patients with pancreatic cancer, which may lead to leukocyte dysfunction. Overexpression of TLR4, NOD1 and TRAF6 genes, and decreased MyD88 gene expression may contribute to chronic inflammation and tumor progression by up-regulation of the innate antibacterial response. The parameters tested are useful for monitoring innate immunity gene disorders and pancreatic cancer progression.

keywords:

Clinical immunologyGene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression

Robert Słotwiński , Aleksandra Dąbrowska , Gustaw Lech , Maciej Słodkowski , Sylwia M. Słotwińska

gene expression, innate immunity, pancreatic cancer

Clinical immunology
Gene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression

Robert Słotwiński

,

Aleksandra Dąbrowska

,

Gustaw Lech

,

Maciej Słodkowski

,

Sylwia M. Słotwińska