Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region

Ashwini Budrukkar; Archya Dasgupta; Prakash Pandit; Sarbani Ghosh Laskar; Vedang Murthy; Ritu Raj Upreti; Tejpal Gupta; Kanchan Dholam; Jai Prakash Agarwal

doi:10.5114/jcb.2017.66773

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region

Ashwini Budrukkar

,

Archya Dasgupta

,

Prakash Pandit

,

Sarbani Ghosh Laskar

,

Vedang Murthy

,

Ritu Raj Upreti

,

Tejpal Gupta

,

Kanchan Dholam

,

Jai Prakash Agarwal

J Contemp Brachytherapy 2017; 9, 3: 242–250

DOI: https://doi.org/10.5114/jcb.2017.66773

Online publish date: 2017/03/23

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AMA

Budrukkar A, Dasgupta A, Pandit P, et al. Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region. Journal of Contemporary Brachytherapy. 2017;9(3):242-250. doi:10.5114/jcb.2017.66773.

APA

Budrukkar, A., Dasgupta, A., Pandit, P., Laskar, S., Murthy, V.,  & Upreti, R. et al. (2017). Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region. Journal of Contemporary Brachytherapy, 9(3), 242-250. https://doi.org/10.5114/jcb.2017.66773

Chicago

Budrukkar, Ashwini, Archya Dasgupta, Prakash Pandit, Sarbani Ghosh Laskar, Vedang Murthy, Ritu Raj Upreti,  and Tejpal Gupta et al. 2017. "Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region". Journal of Contemporary Brachytherapy 9 (3): 242-250. doi:10.5114/jcb.2017.66773.

Harvard

Budrukkar, A., Dasgupta, A., Pandit, P., Laskar, S., Murthy, V., Upreti, R., Gupta, T., Dholam, K.,  and Agarwal, J. (2017). Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region. Journal of Contemporary Brachytherapy, 9(3), pp.242-250. https://doi.org/10.5114/jcb.2017.66773

MLA

Budrukkar, Ashwini et al. "Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region." Journal of Contemporary Brachytherapy, vol. 9, no. 3, 2017, pp. 242-250. doi:10.5114/jcb.2017.66773.

Vancouver

Budrukkar A, Dasgupta A, Pandit P, Laskar S, Murthy V, Upreti R et al. Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region. Journal of Contemporary Brachytherapy. 2017;9(3):242-250. doi:10.5114/jcb.2017.66773.

Purpose: The literature and experience of high-dose-rate (HDR) surface mould brachytherapy (SMB) in head and neck cancer is sparse. We report our institutional experience of SMB for such tumours.

Material and methods: Thirty-five patients with malignant localized early T1/T2, N0 (21 intra-oral and 14 skin) tumours treated with SMB during 2008-2014 were analyzed. Treatment was delivered using HDR 192Ir source to a median dose of 49 Gy (range, 38.5-52.5 Gy) as radical brachytherapy and 18 Gy (range, 15.5-30 Gy) as boost with 3-4 Gy/fraction twice daily using customized surface mould.

Results: Median follow-up was 52 months (range, 6 to 98 months). Local control (LC) for skin tumours and intra-oral malignancies at 5 years were 92% and 76%, respectively. Five-year cause specific survival was 92%. For T1 and T2 tumours, 5 year LC was 94.2% and 68.2%, respectively. T stage (p < 0.04) and dose/fractions (p < 0.003) were the only significant prognostic factors for LC on univariate analysis.

Conclusions: Surface mould brachytherapy results in excellent LC rates for skin tumours and T1 intraoral tumours when considered as radical treatment, and preferable to consider it as a boost for T2 intraoral tumours. Surface mould brachytherapy results in excellent organ and function preservation.

keywords:

Clinical outcomes with high-dose-rate surface mould brachytherapy for intra-oral and skin malignancies involving head and neck region

Ashwini Budrukkar , Archya Dasgupta , Prakash Pandit , Sarbani Ghosh Laskar , Vedang Murthy , Ritu Raj Upreti , Tejpal Gupta , Kanchan Dholam , Jai Prakash Agarwal

brachytherapy, head and neck, skin, surface mould

Ashwini Budrukkar

,

Archya Dasgupta

,

Prakash Pandit

,

Sarbani Ghosh Laskar

,

Vedang Murthy

,

Ritu Raj Upreti

,

Tejpal Gupta

,

Kanchan Dholam

,

Jai Prakash Agarwal