Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Anna Rzehak; Michał Sobstyl; Teresa Wierzba-Bobrowicz; Piotr Bojarski; Wiesława Grajkowska

doi:10.5114/fn.2021.109409

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2021
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abstract:

Case report

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Anna Rzehak

¹

,

Michał Roman Sobstyl

¹

,

Teresa Wierzba-Bobrowicz

²

,

Piotr Bojarski

¹

,

Wiesława Grajkowska

³

Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Pathomorphology, Centre of Postgraduate Medical Education, Warsaw, Poland

Folia Neuropathol 2021; 59 (3): 322-326

DOI: https://doi.org/10.5114/fn.2021.109409

Online publish date: 2021/10/05

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AMA

Rzehak A, Sobstyl MR, Wierzba-Bobrowicz T, Bojarski P, Grajkowska W. Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report. Folia Neuropathologica. 2021;59(3):322-326. doi:10.5114/fn.2021.109409.

APA

Rzehak, A., Sobstyl, M. R., Wierzba-Bobrowicz, T., Bojarski, P.,  & Grajkowska, W. (2021). Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report. Folia Neuropathologica, 59(3), 322-326. https://doi.org/10.5114/fn.2021.109409

Chicago

Rzehak, Anna, Michał R Sobstyl, Teresa Wierzba-Bobrowicz, Piotr Bojarski,  and Wiesława Grajkowska. 2021. "Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report". Folia Neuropathologica 59 (3): 322-326. doi:10.5114/fn.2021.109409.

Harvard

Rzehak, A., Sobstyl, M., Wierzba-Bobrowicz, T., Bojarski, P.,  and Grajkowska, W. (2021). Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report. Folia Neuropathologica, 59(3), pp.322-326. https://doi.org/10.5114/fn.2021.109409

MLA

Rzehak, Anna et al. "Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report." Folia Neuropathologica, vol. 59, no. 3, 2021, pp. 322-326. doi:10.5114/fn.2021.109409.

Vancouver

Rzehak A, Sobstyl M, Wierzba-Bobrowicz T, Bojarski P, Grajkowska W. Clinical presentation of neuroendocrine cancer metastasis 
to an anterior clinoid process meningioma invading superior orbital fissure. A case report. Folia Neuropathologica. 2021;59(3):322-326. doi:10.5114/fn.2021.109409.

PlumX metrics:

Metastasis to a meningioma is an uncommon phenomenon however reported in the literature. Meningiomas are common primary intracranial tumours which most frequently occur to be a recepient of metastases. A 66-year-old female presented with rapid development of visual acuity and visual field loss in the right eye with ipsilateral oculomotor nerve palsy. Magnetic resonance imaging (MRI) showed well-defined tumour intensely enhanced with contrast like a typical skull base meningioma. The neuropathological examination revealed two different morphological fragments of the tumour. In the cell-rich part of the tumour, immunopositivity for CK, chromogranin, and SY were detected. The less cellular portion of the tumour, immunopositivity to epithelial membrane antigen (EMA) and vimentin were detected. To our knowledge, we present the first rare metastasis of neuroendocrine carcinoma to the medial sphenoid meningioma that preceded the clinical symptoms of systemic neuroendocrine carcinoma.

keywords:

Clinical presentation of neuroendocrine cancer metastasis to an anterior clinoid process meningioma invading superior orbital fissure. A case report

Anna Rzehak 1 , Michał Roman Sobstyl 1 , Teresa Wierzba-Bobrowicz 2 , Piotr Bojarski 1 , Wiesława Grajkowska 3

neuroendocrine cancer, meningioma, brain metastasis, tumour-to-meningioma metastasis

Anna Rzehak

¹

,

Michał Roman Sobstyl

¹

,

Teresa Wierzba-Bobrowicz

²

,

Piotr Bojarski

¹

,

Wiesława Grajkowska

³