Cognitive impairment in COVID-19 patients and its relation to laboratory data

Hannan Ebrahimi; Maral Moafi; Amir Kian Moaveni; Mohammad Javad Ebrahimi; Ahmad Pour-Rashidi; Hesam Azimi; Azar Hadadi; Mahnaz Montazeri; Marziyeh Pazoki; Samira Kafan; Shahin Nasseri; Maryam Aghayerashti; Gilda Kianimehr; Abbas Amirjamshidi

doi:10.5114/nan.2023.129076

eISSN: 2084-9885
ISSN: 1896-6764

Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology

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1-2/2023
vol. 18

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abstract:

Original article

Cognitive impairment in COVID-19 patients and its relation to laboratory data

Hannan Ebrahimi

¹

,

Maral Moafi

¹

,

Amir Kian Moaveni

¹

,

Mohammad Javad Ebrahimi

¹

,

Ahmad Pour-Rashidi

¹

,

Hesam Azimi

¹

,

Azar Hadadi

²

,

Mahnaz Montazeri

²

,

Marziyeh Pazoki

³

,

Samira Kafan

³

,

Shahin Nasseri

¹

,

Maryam Aghayerashti

⁴

,

Gilda Kianimehr

⁵

,

Abbas Amirjamshidi

¹

Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Department of Infectious Disease, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Department of Pulmonary Disease, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
PhD candidate of statistics, Faculty of Mathematical Science, Shahid Beheshti University, Tehran, Iran
Department of Psychiatry, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Neuropsychiatria i Neuropsychologia 2023; 18, 1–2: 85–91

DOI: https://doi.org/10.5114/nan.2023.129076

Online publish date: 2023/07/03

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AMA

Ebrahimi H, Moafi M, Moaveni A, et al. Cognitive impairment in COVID-19 patients and its relation to laboratory data. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2023;18(1):85-91. doi:10.5114/nan.2023.129076.

APA

Ebrahimi, H., Moafi, M., Moaveni, A., Ebrahimi, M., Pour-Rashidi, A.,  & Azimi, H. et al. (2023). Cognitive impairment in COVID-19 patients and its relation to laboratory data. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 18(1), 85-91. https://doi.org/10.5114/nan.2023.129076

Chicago

Ebrahimi, Hannan, Maral Moafi, Amir Kian Moaveni, Mohammad Javad Ebrahimi, Ahmad Pour-Rashidi, Hesam Azimi,  and Azar Hadadi et al. 2023. "Cognitive impairment in COVID-19 patients and its relation to laboratory data". Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology 18 (1): 85-91. doi:10.5114/nan.2023.129076.

Harvard

Ebrahimi, H., Moafi, M., Moaveni, A., Ebrahimi, M., Pour-Rashidi, A., Azimi, H., Hadadi, A., Montazeri, M., Pazoki, M., Kafan, S., Nasseri, S., Aghayerashti, M., Kianimehr, G.,  and Amirjamshidi, A. (2023). Cognitive impairment in COVID-19 patients and its relation to laboratory data. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, 18(1), pp.85-91. https://doi.org/10.5114/nan.2023.129076

MLA

Ebrahimi, Hannan et al. "Cognitive impairment in COVID-19 patients and its relation to laboratory data." Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology, vol. 18, no. 1, 2023, pp. 85-91. doi:10.5114/nan.2023.129076.

Vancouver

Ebrahimi H, Moafi M, Moaveni A, Ebrahimi M, Pour-Rashidi A, Azimi H et al. Cognitive impairment in COVID-19 patients and its relation to laboratory data. Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology. 2023;18(1):85-91. doi:10.5114/nan.2023.129076.

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Introduction:
Neuropsychological manifestations are increasingly reported in patients with COVID-19, but the subject is poorly understood and our knowledge about cognitive impairment is limited. This study aimed to investigate neuropsychological involvement of COVID-19 and its relation to laboratory data.

Material and methods:
This study was conducted among patients admitted to a tertiary medical center in Iran, in the period March 2020 to March 2021. Neuropsychiatric assessments were carried out by the Addenbrooke’s Cognitive Examination (ACE) test in all patients and interpreted by a specialist. It was performed using the Persian version of ACE in six domains consisting of attention, orientation, memory, language, visual perception and visuospatial skills. Laboratory data were assessed among all patients. Statistical analyses were performed using SPSS.

Results:
Among 114 patients with COVID-19, the mean age was 48.46 ±13.61 years, and the male/female ratio was 1.32. The mean values of some abnormal laboratory data were: erythrocyte sedimentation rate (ESR) 57.2 ±29.8, C-reactive protein (CRP) 81.7 ±59.8 and D-dimer 459.3 ±395.4. Cognitive impairment was detected in 41 patients (63%). The mean score of ACE was 80.68 ±19.29. Statistical analysis showed correlations between total result of the ACE test and laboratory findings that were not statistically significant.

Conclusions:
In our study, no relation was found between laboratory test results and the overall cognitive examination score but statistical analysis showed a correlation between CRP and verbal fluency, between hemoglobin level and language and visuospatial domains, and also between total level of bilirubin and memory. These relations may suggest that we should follow the neurocognitive features in COVID-19 patients earlier.

keywords:

Cognitive impairment in COVID-19 patients and its relation to laboratory data

Hannan Ebrahimi 1 , Maral Moafi 1 , Amir Kian Moaveni 1 , Mohammad Javad Ebrahimi 1 , Ahmad Pour-Rashidi 1 , Hesam Azimi 1 , Azar Hadadi 2 , Mahnaz Montazeri 2 , Marziyeh Pazoki 3 , Samira Kafan 3 , Shahin Nasseri 1 , Maryam Aghayerashti 4 , Gilda Kianimehr 5 , Abbas Amirjamshidi 1

COVID-19, cognitive impairment, neuropsychological involvement, laboratory data