eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
4/2024
vol. 19
 
Share:
Send email
Share:
Review paper

Colorectal cancer and microbiota: systematic review

Nauryzbay Imanbayev
1
,
Yerbolat Iztleuov
2
,
Yerbol Bekmukhambetov
3
,
Ibrahim A. Abdelazim
4
,
Ainur Donayeva
5
,
Ainur Amanzholkyzy
5
,
Zhumasheva Aigul
6
,
Imanbayeva Aigerim
1
,
Yergaliyev Aslan
7

  1. Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  2. Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  3. Association of Individual Entrepreneurs and Legal Entities, National Chamber of Health, Astana, Kazakhstan
  4. Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
  5. Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  6. Department of Pathomorphology, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
  7. Department of General Surgery, Medical Centre of West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Gastroenterology Rev 2024; 19 (4): 380–396
DOI: https://doi.org/10.5114/pg.2024.136228
Online publish date: 2024/03/11
Article file
- Colorectal cancer (1).pdf  [0.17 MB]
Get citation
 
PlumX metrics:
 
1. Henrikson NB, Webber EM, Goddard KA, et al. Family history and the natural history of colorectal cancer: systematic review. Genet Med 2015; 17: 702-12.
2. Syngal S, Brand RE, Church JM, et al.; American College of Gastroenterology. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol 2015; 110: 223-62.
3. Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer. Lancet 2019; 394: 1467-80.
4. Jones RL. Gut microbiome as a potential biomarker of cancer risk in inflammatory bowel disease. Contemp Oncol (Pozn) 2022; 26: 40-3.
5. Medema JP. Cancer stem cells: the challenges ahead. Nat Cell Biol 2013; 15: 338-44.
6. Stappenbeck TS, Virgin HW. Accounting for reciprocal host-microbiome interactions in experimental science.
7. Nature 2016; 534: 191-9.
8. Zitvogel L, Ma Y, Raoult D, et al. The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies. Science 2018; 359: 1366-70.
9. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J 2017; 474: 1823-36.
10. Markowiak-Kopeć P, Śliżewska K. the effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients 2020; 12: 1107.
11. Lin Y, Ma C, Liu C, et al. NMR-based fecal metabolomics fingerprinting as predictors of earlier diagnosis in patients with colorectal cancer. Oncotarget 2016; 7: 29454-64.
12. Chen J, Vitetta L. Inflammation-modulating effect of butyrate in the prevention of colon cancer by dietary fiber. Clin Colorectal Cancer 2018; 17: e541-4.
13. Zeng H, Safratowich BD, Wang TTY, et al. Butyrate inhibits deoxycholic-acid-resistant colonic cell proliferation via cell cycle arrest and apoptosis: a potential pathway linking dietary fiber to cancer prevention. Mol Nutr Food Res 2020; 64: e1901014.
14. Zhao Y, Chen F, Wu W, et al. GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3. Mucosal Immunol 2018; 11: 752-62.
15. Eeckhaut V, Machiels K, Perrier C, et al. Butyricicoccus pullicaecorum in inflammatory bowel disease. Gut 2013; 62: 1745-52.
16. Wang G, Yu Y, Wang YZ, et al. Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy. J Cell Physiol 2019; 234: 17023-49.
17. Takaishi H, Matsuki T, Nakazawa A, et al. Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease. Int J Med Microbiol 2008; 298: 463-72.
18. Vigsnæs LK, Brynskov J, Steenholdt C, et al. Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controls. Benef Microbes 2012; 3: 287-97.
19. Wang L, Tang L, Feng Y, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice. Gut 2020; 69: 1988-97.
20. Wong SH, Yu J. Gut microbiota in colorectal cancer: mechanisms of action and clinical applications. Nat Rev Gastroenterol Hepatol 2019; 16: 690-704.
21. Peters BA, Dominianni C, Shapiro JA, et al. The gut microbiota in conventional and serrated precursors of colorectal cancer. Microbiome 2016; 4: 69.
22. Dethlefsen L, Huse S, Sogin ML, et al. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 2008; 6: e280.
23. Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179-85.
24. Newton DF, Cummings JH, Macfarlane S, et al. Growth of a human intestinal Desulfovibrio desulfuricans in continuous cultures containing defined populations of saccharolytic and amino acid fermenting bacteria. J Appl Microbiol 1998; 85: 372-80.
25. Carbonero F, Benefiel AC, Gaskins HR. Contributions of the microbial hydrogen economy to colonic homeostasis. Nat Rev Gastroenterol Hepatol 2012; 9: 504-18.
26. Cai WJ, Wang MJ, Ju LH, et al. Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21. Cell Biol Int 2010; 34: 565-72.
27. Kanazawa K, Konishi F, Mitsuoka T, et al. Factors influencing the development of sigmoid colon cancer. Bacteriologic and biochemical studies. Cancer 1996; 77: 1701-6.
28. Kostic AD, Gevers D, Pedamallu CS, et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res 2012; 22: 292-8.
29. Castellarin M, Warren RL, Freeman JD, et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res 2012; 22: 299-306.
30. Feng Q, Liang S, Jia H, et al. Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun 2015; 6: 6528.
31. Garrett WS. The gut microbiota and colon cancer. Science 2019; 364: 1133-5.
32. Dejea CM, Fathi P, Craig JM, et al. Patients with familial adenomatous polyposis harbor colonic biofilms containing tumourigenic bacteria. Science 2018; 359: 592-7.
33. Turnbaugh PJ, Hamady M, Yatsunenko T, et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480-4.
34. De Filippis F, Pellegrini N, Vannini L, et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut 2016; 65: 1812-21.
35. Donohoe DR, Holley D, Collins LB, et al. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumourigenesis in a microbiota- and butyrate-dependent manner. Cancer Discov 2014; 4: 1387-97.
36. Halmos EP, Power VA, Shepherd SJ, et al. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 2014; 146: 67-75. e5.
37. Sanders ME, Merenstein DJ, Reid G, et al. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 2019; 16: 605-16.
38. Azcárate-Peril MA, Sikes M, Bruno-Bárcena JM. The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol 2011; 301: G401-24.
39. Zhuo Q, Yu B, Zhou J, et al. Lysates of Lactobacillus acidophilus combined with CTLA-4-blocking antibodies enhance antitumour immunity in a mouse colon cancer model. Sci Rep 2019; 9: 20128.
40. Nami Y, Haghshenas B, Haghshenas M, et al. The prophylactic effect of probiotic Enterococcus lactis IW5 against different human cancer cells. Front Microbiol 2015; 6: 1317.
41. Kaeid Sharaf L, Shukla G. Probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in conjunction with celecoxib (selective COX-2 inhibitor) modulated DMH-induced early experimental colon carcinogenesis. Nutr Cancer 2018; 70: 946-55.
42. Sharaf LK, Sharma M, Chandel D, et al. Prophylactic intervention of probiotics (L. acidophilus, L. rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis. BMC Cancer 2018; 18: 1111.
43. Bajramagic S, Hodzic E, Mulabdic A, et al. Usage of probiotics and its clinical significance at surgically treated patients sufferig from colorectal carcinoma. Med Arch 2019; 73: 316-20.
44. Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA 2013; 110: 9066-71.
45. Gopalakrishnan V, Spencer CN, Nezi L, et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 2018; 359: 97-103.
46. Paolillo R, Romano Carratelli C, Sorrentino S, et al. Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells. Int Immunopharmacol 2009; 9: 1265-71.
47. Kahouli I, Malhotra M, Westfall S, et al. Design and validation of an orally administrated active L. fermentum-L. acidophilus probiotic formulation using colorectal cancer Apc Min/+ mouse model. Appl Microbiol Biotechnol 2017; 101: 1999-2019.
48. Zhu J, Zhu C, Ge S, et al. Lactobacillus salivarius Ren prevent the early colorectal carcinogenesis in 1, 2-dimethylhydrazine-induced rat model. J Appl Microbiol 2014; 117: 208-16.
49. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017; 14: 491-502.
50. van Loo J, Coussement P, de Leenheer L, et al. On the presence of inulin and oligofructose as natural ingredients in the western diet. Crit Rev Food Sci Nutr 1995; 35: 525-52.
51. Roberfroid MB, Van Loo JA, Gibson GR. The bifidogenic nature of chicory inulin and its hydrolysis products. J Nutr 1998; 128: 11-9.
52. Campbell JM, Fahey GC Jr, Wolf BW. Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats. J Nutr 1997; 127: 130-6.
53. Fehlbaum S, Prudence K, Kieboom J, et al. In vitro fermentation of selected prebiotics and their effects on the composition and activity of the adult gut microbiota. Int J Mol Sci 2018; 19: 3097.
54. Li K, Zhang L, Xue J, et al. Dietary inulin alleviates diverse stages of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in db/db mice. Food Funct 2019; 10: 1915-27.
55. Faraj A, Vasanthan T. Hoover R. The effect of extrusion cooking on resistant starch formation in waxy and regular barley flours. Food Research International 2004; 37: 517-25.
56. Swanson KS, Gibson GR, Hutkins R, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of symbiotics. Nat Rev Gastroenterol Hepatol 2020; 17: 687-701.
57. Paulos CM, Wrzesinski C, Kaiser A, et al. Microbial translocation augments the function of adoptively transferred self/tumour-specific CD8+ T cells via TLR4 signaling. J Clin Invest 2007; 117: 2197-204.
58. Viaud S, Saccheri F, Mignot G, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 2013; 342: 971-6.
59. Vétizou M, Pitt JM, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 2015; 350: 1079-84.
60. Ganesh K, Stadler ZK, Cercek A, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Rev Gastroenterol Hepatol 2019; 16: 361-75.
61. Routy B, Le Chatelier E, Derosa L, et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumours. Science 2018; 359: 91-7.
62. Alberda WJ, Verhoef C, Schipper ME, et al. The importance of a minimal tumour-free resection margin in locally recurrent rectal cancer. Dis Colon Rectum 2015; 58: 677-85.
63. Manfredi S, Bouvier AM, Lepage C, et al. Incidence, and patterns of recurrence after resection for cure of colonic cancer in a well-defined population. Br J Surg 2006; 93: 1115-22.
64. Naxerova K, Reiter JG, Brachtel E, et al. Origins of lymphatic and distant metastases in human colorectal cancer. Science 2017; 357: 55-60.
65. Shogan BD, Belogortseva N, Luong PM, et al. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med 2015; 7: 286ra68.
66. Gaines S, van Praagh JB, Williamson AJ, et al. Western diet promotes intestinal colonization by collagenolytic microbes and promotes tumour formation after colorectal surgery. Gastroenterology 2020; 158: 958-70.e2.
67. Yuan L, Zhang S, Li H, et al. The influence of gut microbiota dysbiosis to the efficacy of 5-fluorouracil treatment on colorectal cancer. Biomed Pharmacother 2018; 108: 184-93.
68. Song H, Wang W, Shen B, et al. Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: transcriptome and gut flora profiling. Cancer Sci 2018; 109: 666-77.
69. Chen CC, Lin WC, Kong MS, et al. Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue. Br J Nutr 2012; 107: 1623-34.
70. Mendes MCS, Paulino DS, Brambilla SR, et al. Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice. World J Gastroenterol 2018; 24: 1995-2008.
71. Chung EJ, Do EJ, Kim SY, et al. Combination of metformin and VSL#3 additively suppresses western-style diet induced colon cancer in mice. Eur J Pharmacol 2017; 794: 1-7.
72. Arthur JC, Gharaibeh RZ, Uronis JM, et al. VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer. Sci Rep 2013; 3: 2868.
73. Chang CW, Liu CY, Lee HC, et al. Lactobacillus casei Variety rhamnosus probiotic preventively attenuates 5-fluorouracil/oxaliplatin-induced intestinal injury in a syngeneic colorectal cancer model. Front Microbiol 2018; 9: 983.
74. Jacouton E, Chain F, Sokol H, et al. Probiotic strain Lactobacillus casei BL23 prevents colitis-associated colorectal cancer. Front Immunol 2017; 8: 1553.
75. Gao C, Ganesh BP, Shi Z, et al. Gut microbe-mediated suppression of inflammation-associated colon carcinogenesis by luminal histamine production. Am J Pathol 2017; 187: 2323-36.
76. Shi L, Sheng J, Chen G, et al. Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumour immune response and tumour clearance. J Immunother Cancer 2020; 8: e000973.
77. Bellville JW, Swanson GD, Miyake T, et al. Respiratory stimulation observed following ethanol ingestion. West J Med 1976; 124: 423-5.
78. Shinohara K, Ohashi Y, Kawasumi K, et al. Effect of apple intake on fecal microbiota and metabolites in humans. Anaerobe 2010; 16: 510-5.
79. Schwartz SE, Levine RA, Weinstock RS, et al. Sustained pectin ingestion: effect on gastric emptying and glucose tolerance in non-insulin-dependent diabetic patients. Am J Clin Nutr 1988; 48: 1413-7.
80. Annunziata G, Maisto M, Schisano C, et al. Effect of grape pomace polyphenols with or without pectin on TMAO serum levels assessed by LC/MS-based assay: a preliminary clinical study on overweight/obese subjects. Front Pharmacol 2019; 10: 575.
81. Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res 2009; 344: 1788-91.
82. Zhang SL, Mao YQ, Zhang ZY, et al. Pectin supplement significantly enhanced the anti-PD-1 efficacy in tumour-bearing mice humanized with gut microbiota from patients with colorectal cancer. Theranostics 2021; 11: 4155-70.
83. Bruno-Barcena JM, Azcarate-Peril MA. Galacto-oligosaccharides and colorectal cancer: feeding our intestinal probiome. J Funct Foods 2015; 12: 92-108.
84. Li Y, Elmén L, Segota I, Xian Y, et al. Prebiotic-induced anti-tumour immunity attenuates tumour growth. Cell Rep 2020; 30: 1753-66.e6.
85. Hibberd AA, Lyra A, Ouwehand AC, et al. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. BMJ Open Gastroenterol 2017; 4: e000145.
86. Warburg O. On the origin of cancer cells. Science 1956; 123: 309-14.
87. Roediger WE. Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 1980; 21: 793-8.
88. Wu JC, Tsai ML, Lai CS, et al. Polymethoxyflavones prevent benzo[a]pyrene/dextran sodium sulfate-induced colorectal carcinogenesis through modulating xenobiotic metabolism and ameliorate autophagic defect in ICR mice. Int J Cancer 2018; 142: 1689-701.
89. Hu Y, Le Leu RK, Christophersen CT, et al. Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats. Carcinogenesis 2016; 37: 366-75.
90. Zhang H, Hui D, Li Y, et al. Canmei formula reduces colitis-associated colorectal carcinogenesis in mice by modulating the composition of gut microbiota. Front Oncol 2019; 9: 1149.
91. Chou YC, Suh JH, Wang Y, et al. Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumourigenesis. Mol Nutr Food Res 2017; 61. doi: 10.1002/mnfr.201600984.
92. Zheng DW, Li RQ, An JX, et al. Prebiotics-encapsulated probiotic spores regulate gut microbiota and suppress colon cancer. Adv Mater 2020; 32: e2004529.
93. Khan I, Huang G, Li XA, et al. Mushroom polysaccharides and jiaogulan saponins exert cancer preventive effects by shaping the gut microbiota and microenvironment in ApcMin/+ mice. Pharmacol Res 2019; 148: 104448.
94. Chen L, Jiang B, Zhong C, et al. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis 2018; 39: 471-81.
95. Chandel D, Sharma M, Chawla V, et al. Isolation, characterization, and identification of antigenotoxic and anticancerous indigenous probiotics and their prophylactic potential in experimental colon carcinogenesis. Sci Rep 2019; 9: 14769.
96. Silveira DSC, Veronez LC, Lopes-Júnior LC, et al. Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model. World J Gastroenterol 2020; 26: 6782-94.
97. Oh NS, Lee JY, Kim YT, et al. Cancer-protective effect of a symbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer. Gut Microbes 2020; 12: 1785803.
98. Khoo HE, Azlan A, Tang ST, et al. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res 2017; 61: 1361779.
99. Rudd DA, Benkendorff K, Chahal C, et al. Mapping insoluble indole metabolites in the gastrointestinal environment of a murine colorectal cancer model using desorption/ionisation on porous silicon imaging. Sci Rep 2019; 9: 12342.
100. Reglero C, Reglero G. Precision nutrition and cancer relapse prevention: a systematic literature review. Nutrients 2019; 11: 2799.
101. Terasaki M, Uehara O, Ogasa S, et al. Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice. Carcinogenesis 2021; 42: 210-9.
102. Li F, Yang XW, Krausz KW, et al. Modulation of colon cancer by nutmeg. J Proteome Res 2015; 14: 1937-46.
103. Toledo E, Salas-Salvadó J, Donat-Vargas C, et al. Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: a randomized clinical trial. JAMA Intern Med 2015; 175: 1752-60.
104. Bamia C, Lagiou P, Buckland G, et al. Mediterranean diet, and colorectal cancer risk: results from a European cohort. Eur J Epidemiol 2013; 28: 317-28.
105. Piazzi G, Prossomariti A, Baldassarre M, et al. A Mediterranean diet mix has chemopreventive effects in a murine model of colorectal cancer modulating apoptosis and the gut microbiota. Front Oncol 2019; 9: 140.
106. Zhang JW, Du P, Gao J, et al. Preoperative probiotics decrease postoperative infectious complications of colorectal cancer. Am J Med Sci 2012; 343: 199-205.
107. Liu Z, Qin H, Yang Z, et al. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery – a double-blind study. Aliment Pharmacol Ther 2011; 33: 50-63.
108. Aisu N, Tanimura S, Yamashita Y, et al. Impact of perioperative probiotic treatment for surgical site infections in patients with colorectal cancer. Exp Ther Med 2015; 10: 966-72.
109. So WKW, Chan JYW, Law BMH, et al. Effects of a rice bran dietary intervention on the composition of the intestinal microbiota of adults with a high risk of colorectal cancer: a pilot randomised-controlled trial. Nutrients 2021; 13: 526.
110. Xie X, He Y, Li H, et al. Effects of prebiotics on immunologic indicators and intestinal microbiota structure in perioperative colorectal cancer patients. Nutrition 2019; 61: 132-42.
111. Polakowski CB, Kato M, Preti VB, et al. Impact of the preoperative use of symbiotics in colorectal cancer patients: a prospective, randomized, double-blind, placebo-controlled study. Nutrition 2019; 58: 40-6.
112. Nuñez-Sánchez MA, González-Sarrías A, García-Villalba R, et al. Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. J Nutr Biochem 2017; 42: 126-33.
113. Nuñez-Sánchez MA, Dávalos A, González-Sarrías A, et al. MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts. Mol Nutr Food Res 2015; 59: 1973-86.
114. Xu H, Hiraishi K, Kurahara LH, et al. Inhibitory effects of breast milk-derived Lactobacillus rhamnosus Probio-M9 on colitis-associated carcinogenesis by restoration of the gut microbiota in a mouse model. Nutrients 2021; 13: 1143.
115. Chang SC, Shen MH, Liu CY, et al. A gut butyrate-producing bacterium Butyricicoccus pullicaecorum regulates short-chain fatty acid transporter and receptor to reduce the progression of 1,2-dimethylhydrazine-associated colorectal cancer. Oncol Lett 2020; 20: 327.
116. Hradicka P, Beal J, Kassayova M, et al. A novel lactic acid bacteria mixture: macrophage-targeted prophylactic intervention in colorectal cancer management. Microorganisms 2020; 8: 387.
117. Bindels LB, Neyrinck AM, Loumaye A, et al. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance. Oncotarget 2018; 9: 18224-38.
118. da Silva Duarte V, Dos Santos Cruz BC, Tarrah A, et al. Chemoprevention of DMH-induced early colon carcinogenesis in male BALB/c mice by administration of Lactobacillus Paracasei DTA81. Microorganisms 2020; 8: 1994.
119. Zhu LQ, Zhang L, Zhang J, et al. Evodiamine inhibits high-fat diet-induced colitis-associated cancer in mice through regulating the gut microbiota. J Integr Med 2021; 19: 56-65.
120. Luo L, Yan J, Chen B, et al. The effect of menthol supplement diet on colitis-induced colon tumourigenesis and intestinal microbiota. Am J Transl Res 2021; 13: 38-56.
121. Liu X, Wang L, Jing N, et al. Biostimulating gut microbiome with bilberry anthocyanin combo to enhance anti-PD-L1 efficiency against murine colon cancer. Microorganisms 2020; 8: 175.
122. Fernández J, Moreno FJ, Olano A, et al. A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model. Front Microbiol 2018; 9: 2004.
123. Mudd AM, Gu T, Munagala R, et al. Chemoprevention of colorectal cancer by anthocyanidins and mitigation of metabolic shifts induced by dysbiosis of the gut microbiome. Cancer Prev Res (Phila) 2020; 13: 41-52.
124. Fukuda M, Komiyama Y, Mitsuyama K, et al. Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. J Clin Biochem Nutr 2011; 49: 57-61.
125. Yu C, Wen XD, Zhang Z, et al. American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice. J Ginseng Res 2015; 39: 230-7.
126. Gianotti L, Morelli L, Galbiati F, et al. A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol 2010; 16: 167-75.
127. Worthley DL, Le Leu RK, Whitehall VL, et al. A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and symbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 2009; 90: 578-86.
128. Brown DG, Borresen EC, Brown RJ, et al. Heat-stabilised rice bran consumption by colorectal cancer survivors modulates stool metabolite profiles and metabolic networks: a randomised controlled trial. Br J Nutr 2017; 117: 1244-56.
Copyright: © 2024 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.