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Folia Neuropathologica
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3/2023
vol. 61
 
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abstract:
Original paper

Correlation between blood pressure variability and deep cerebral microbleeds in patients with acute ischemic stroke

Yaya Bao
1
,
Jiayi Gu
2
,
Tian Lv
3
,
Miao Chen
3
,
Ke Zhao
3
,
Yue Yang
3
,
Dadong Gu
3

  1. Department of Neurology, Shaoxing University School of Medicine, Shaoxing, China
  2. Jitang College of North China University of Science and Technology, Tangshan, China
  3. Department of Neurology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, China
Folia Neuropathol 2023; 61 (3): 309-316
DOI: https://doi.org/10.5114/fn.2023.130006
Online publish date: 2023/09/08
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Introduction:
To observe the 24-h ambulatory blood pressure characteristics of patients with acute ischemic stroke and explore the correlation between blood pressure variability and strictly deep cerebral microbleeds (CMBs).

Material and methods:
A convenient sampling method was used to enrol 131 patients with acute ischemic stroke in the Department of Neurology between April 2021 and May 2022. Hospitalised patients with acute ischemic stroke were assessed retrospectively; their ambulatory blood pressure was monitored continuously for 24 h, and the relevant parameters were recorded. Magnetic susceptibility-weighted imaging was used to divide the CMBs into a strictly deep CMB group (n = 24) and a non-CMB group (n = 107) according to the location of the CMBs. A logistic regression analysis was performed to determine the independent correlation between the 24-h ambulatory blood pressure parameters and strictly deep CMBs. The receiver operating characteristic (ROC) was further used to analyse the predictive value of the ambulatory blood pressure parameters for strictly deep CMBs in patients with acute ischemic stroke.

Results:
The results showed that the night systolic blood pressure standard deviation and the night diastolic blood pressure standard deviation (NDBP-SD) in the strictly deep CMB group were higher than those in the non-CMB group (p < 0.05). The multiple logistic regression analysis indicated that the NDBP-SD (odds ratio [OR] = 1.205, 95% confidence interval [CI]: 1.011-1.436, p = 0.038) was an independent risk factor for strictly deep CMBs in patients. The ROC curve analysis revealed that the area under the curve value of the NDBP-SD was 0.682, and the intercept was 7.81. When NDBP-SD is ≥ 7.81, the occurrence of strictly deep CMBs is closely related (OR = 3.872, 95% CI: 1.347-11.125, p = 0.012).

Conclusions:
The NDBP-SD is an independent risk factor for strictly deep CMBs in patients with acute ischemic stroke. When NDBP-SD is > 7.81, it may promote the production of strictly deep CMBs.

keywords:

acute ischemic stroke, deep brain microbleeds, blood pressure variability
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