Critical factors responsible for the therapeutic effect 
of mesenchymal stem/stromal cells in central nervous system disorders

Anna Figiel-Dąbrowska; Monika Sypecka; Magdalena Chodkowska; Anna Sarnowska

doi:10.5114/fn.2022.114335

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2022
vol. 60

Send email

Copy url:

abstract:

Review paper

Critical factors responsible for the therapeutic effect of mesenchymal stem/stromal cells in central nervous system disorders

Anna Figiel-Dąbrowska

¹

,

Monika Sypecka

¹

,

Magdalena Chodkowska

¹

,

Anna Sarnowska

¹

Translational Platform for Regenerative Medicine, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Folia Neuropathol 2022; 60 (1): 1-9

DOI: https://doi.org/10.5114/fn.2022.114335

Online publish date: 2022/03/29

View full text Get citation

PlumX metrics:

Nowadays it is observed that the number of stem-cell based experimental therapies in neurodegenerative disorders is massively increasing. Most of the clinical trials registered to date have been based on autologous mesenchymal stem/stromal cells (MSC) obtained from somatic tissues. In the conducted clinical trials neither serious side effects, nor statistically significant improvement were observed. The lack of statistical significance could result from a relatively small number of patients involved in clinical trials or highly incoherent study protocols. However, most clinical groups describe a trend towards improvement in MSC-treated patients. Hence, the question arises which factors associated with MSC-based therapy may be the key and result in better therapeutic response. In the presented paper, we summarize, in our opinion, the most important factors that could increase the effectiveness of this therapy.

keywords:

Critical factors responsible for the therapeutic effect of mesenchymal stem/stromal cells in central nervous system disorders

Anna Figiel-Dąbrowska 1 , Monika Sypecka 1 , Magdalena Chodkowska 1 , Anna Sarnowska 1

mesenchymal stem/stromal cells, CNS disorders, intrathecal injection, immunomodulatory properties, therapeutic effect, cell therapy

Anna Figiel-Dąbrowska

¹

,

Monika Sypecka

¹

,

Magdalena Chodkowska

¹

,

Anna Sarnowska

¹