Current study on diagnosis and treatment of Alzheimer’s disease by targeting amyloid b-protein

Kai-Ye Hua; Wei-Jiang Zhao

doi:10.5114/fn.2022.119778

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Review paper

Current study on diagnosis and treatment of Alzheimer’s disease by targeting amyloid b-protein

Kai-Ye Hua

¹

,

Wei-Jiang Zhao

^{1, 2}

Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P.R. China,
Cell Biology Department, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, P.R. China

Folia Neuropathol 2023; 61 (1): 8-15

DOI: https://doi.org/10.5114/fn.2022.119778

Online publish date: 2022/10/21

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Alzheimer’s disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system and is characterized by insidious onset and a chronic progressive course. It is the most common type of senile dementia. Studies have proved that the deposition of amyloid b (Ab) in the brain is one of the initiating factors correlated to the pathology of AD, and it acts as one of the critical factors leading to the onset of AD. A large number of long-term studies have shown that Ab may be a therapeutic target for a breakthrough in the treatment of AD. This review elucidates the important role of Ab in the development of AD, current research on the role of Ab in AD pathogenesis, and treatment of AD by targeting Ab.

keywords:

Current study on diagnosis and treatment of Alzheimer’s disease by targeting amyloid b-protein

Kai-Ye Hua 1 , Wei-Jiang Zhao 1, 2

Alzheimer’s disease, amyloid b, pathogenesis, treatment

Kai-Ye Hua

¹

,

Wei-Jiang Zhao

^{1, 2}