Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome

Michał M. Nowakowski; Mateusz Rubinkiewicz; Natalia Gajewska; Grzegorz Torbicz; Michał Wysocki; Piotr Małczak; Piotr Major; Mateusz Wierdak; Andrzej Budzyński; Michał Pędziwiatr

doi:10.5114/wiitm.2018.76913

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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3/2018
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Original paper

Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome

Michał M. Nowakowski

,

Mateusz Rubinkiewicz

,

Natalia Gajewska

,

Grzegorz Torbicz

,

Michał Wysocki

,

Piotr Małczak

,

Piotr Major

,

Mateusz Wierdak

,

Andrzej Budzyński

,

Michał Pędziwiatr

Videosurgery Miniinv 2018; 13 (3): 306–314

DOI: https://doi.org/10.5114/wiitm.2018.76913

Online publish date: 2018/07/03

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AMA

Nowakowski M, Rubinkiewicz M, Gajewska N, et al. Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome. Videosurgery and Other Miniinvasive Techniques. 2018:306-314. doi:10.5114/wiitm.2018.76913.

APA

Nowakowski, M., Rubinkiewicz, M., Gajewska, N., Torbicz, G., Wysocki, M.,  & Małczak, P. et al. (2018). Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome. Videosurgery and Other Miniinvasive Techniques, 306-314. https://doi.org/10.5114/wiitm.2018.76913

Chicago

Nowakowski, Michał M., Mateusz Rubinkiewicz, Natalia Gajewska, Grzegorz Torbicz, Michał Wysocki, Piotr Małczak,  and Piotr Major et al. 2018. "Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome". Videosurgery and Other Miniinvasive Techniques: 306-314. doi:10.5114/wiitm.2018.76913.

Harvard

Nowakowski, M., Rubinkiewicz, M., Gajewska, N., Torbicz, G., Wysocki, M., Małczak, P., Major, P., Wierdak, M., Budzyński, A.,  and Pędziwiatr, M. (2018). Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome. Videosurgery and Other Miniinvasive Techniques, pp.306-314. https://doi.org/10.5114/wiitm.2018.76913

MLA

Nowakowski, Michał M. et al. "Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome." Videosurgery and Other Miniinvasive Techniques, 2018, pp. 306-314. doi:10.5114/wiitm.2018.76913.

Vancouver

Nowakowski M, Rubinkiewicz M, Gajewska N, Torbicz G, Wysocki M, Małczak P et al. Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome. Videosurgery and Other Miniinvasive Techniques. 2018:306-314. doi:10.5114/wiitm.2018.76913.

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Introduction
Laparoscopic surgery is an approved technique in colorectal cancer treatment. Functional and quality-of-life studies have revealed significant changes in faecal continence.

Aim
To assess the incidence and risk factors of low anterior resection syndrome (LARS) in patients undergoing rectal resections for cancer.

Material and methods
We enrolled patients undergoing rectal resections in a general surgery department of a university hospital. The primary outcomes were the Jorge-Wexner scale and the LARS score 6 months after the end of treatment. The secondary outcomes were the risk factors for LARS development.

Results
Fifty-six patients were included; 15 (26%) developed major LARS and 10 (18%) had minor LARS at 6 months. In univariate analysis the risk factors were: preoperative radiotherapy (p < 0.001, OR = 11.9, 95% CI: 2.98–47.48); shorter distance of the tumour from the anal verge (p = 0.001, OR = 0.69, 95% CI: 0.55–0.86); bowel preparation (p = 0.01, OR = 6.27, 95% CI: 1.51–26.07); low anterior rectal resection (p = 0.01, OR = 17.07, 95% CI: 1.86–156.83); and protective ileostomy (p = 0.001, OR = 15.97, 95% CI: 4.07–61.92). The risk factors for a higher Jorge-Wexner score in univariate analysis were greater diameter of tumour (p = 0.035), radiotherapy (p = 0.001), shorter distance from the anal verge (p = 0.002), bowel preparation (p = 0.042), low anterior rectal (LAR) (p = 0.01), ileostomy (p = 0.001), perioperative complications (p = 0.032), and readmission within 30 days (p = 0.034). In the multivariate analysis, readmissions and perioperative complications were significant.

Conclusions
In addition to typically described risk factors, two new ones have been identified. Mechanical bowel preparation and defunctioning ileostomy may also contribute to LARS development. However, due to the limitations of this study our observations require further confirmation in future trials.

keywords:

Defunctioning ileostomy and mechanical bowel preparation may contribute to development of low anterior resection syndrome

Michał M. Nowakowski , Mateusz Rubinkiewicz , Natalia Gajewska , Grzegorz Torbicz , Michał Wysocki , Piotr Małczak , Piotr Major , Mateusz Wierdak , Andrzej Budzyński , Michał Pędziwiatr

risk factors, rectal cancer, low anterior resection, low anterior resection syndrome, mechanical bowel preparation, ileostomy

Michał M. Nowakowski

,

Mateusz Rubinkiewicz

,

Natalia Gajewska

,

Grzegorz Torbicz

,

Michał Wysocki

,

Piotr Małczak

,

Piotr Major

,

Mateusz Wierdak

,

Andrzej Budzyński

,

Michał Pędziwiatr