Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review

Magdalena Korzycka; Agnieszka J. Osmola-Mańkowska; Monika Bowszyc-Dmochowska; Ryszard Żaba; Zygmunt Adamski

doi:10.5114/dr.2018.79176

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2018
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abstract:

Case report

Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review

Magdalena Korzycka

,

Agnieszka J. Osmola-Mańkowska

,

Monika Bowszyc-Dmochowska

,

Ryszard W. Żaba

,

Zygmunt Adamski

Dermatol Rev/Przegl Dermatol 2018, 105, 632-638

DOI: https://doi.org/10.5114/dr.2018.79176

Online publish date: 2018/11/08

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AMA

Korzycka M, Osmola-Mańkowska A, Bowszyc-Dmochowska M, Żaba RW, Adamski Z. Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review. Dermatology Review/Przegląd Dermatologiczny. 2018;105(5):632-638. doi:10.5114/dr.2018.79176.

APA

Korzycka, M., Osmola-Mańkowska, A., Bowszyc-Dmochowska, M., Żaba, R. W.,  & Adamski, Z. (2018). Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review. Dermatology Review/Przegląd Dermatologiczny, 105(5), 632-638. https://doi.org/10.5114/dr.2018.79176

Chicago

Korzycka, Magdalena, Agnieszka J. Osmola-Mańkowska, Monika Bowszyc-Dmochowska, Ryszard W Żaba,  and Zygmunt Adamski. 2018. "Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review". Dermatology Review/Przegląd Dermatologiczny 105 (5): 632-638. doi:10.5114/dr.2018.79176.

Harvard

Korzycka, M., Osmola-Mańkowska, A., Bowszyc-Dmochowska, M., Żaba, R.,  and Adamski, Z. (2018). Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review. Dermatology Review/Przegląd Dermatologiczny, 105(5), pp.632-638. https://doi.org/10.5114/dr.2018.79176

MLA

Korzycka, Magdalena et al. "Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review." Dermatology Review/Przegląd Dermatologiczny, vol. 105, no. 5, 2018, pp. 632-638. doi:10.5114/dr.2018.79176.

Vancouver

Korzycka M, Osmola-Mańkowska A, Bowszyc-Dmochowska M, Żaba R, Adamski Z. Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review. Dermatology Review/Przegląd Dermatologiczny. 2018;105(5):632-638. doi:10.5114/dr.2018.79176.

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Introduction
Epidermal growth factor receptor inhibitors (EGFR inhibitors) are used for treatment of advanced malignant tumours associated with EGFR overexpression. In over 50% of treated patients dermatological adverse effects are observed, occurring in form of the PRIDE syndrome (papulopustules and/or paronychia, regulatory abnormalities of hair growth, itching and dryness due to epidermal growth factor receptor inhibitors).

Objective
The presented case ilustrates cutaneous adverse events of EGFR inhibitors, an increasing problem in modern medicine.

Case report
A 51-year old man treated with panitumumab for advanced stage of rectal cancer was admitted to the hospital because of a papulopustular rash. A specimen of skin was collected for histopathological analysis and revealed an acne-like rash, typical for EGFR inhibitors.

Conclusions
EGFR inhibitors are a common cause of cutaneous adverse events. Early identification and tretment of these lesions may decrease the risk of adverse-dependent change in oncological threapy.

keywords:

Dermatological adverse effects in a cancer patient treated with an EGFR inhibitor. Case report and literature review

Magdalena Korzycka , Agnieszka J. Osmola-Mańkowska , Monika Bowszyc-Dmochowska , Ryszard W. Żaba , Zygmunt Adamski

skin reactions, EGFR inhibitor, dermatological adverse effects, histopathology

Magdalena Korzycka

,

Agnieszka J. Osmola-Mańkowska

,

Monika Bowszyc-Dmochowska

,

Ryszard W. Żaba

,

Zygmunt Adamski