Diagnosis and surveillance of cardiovascular complications after treatment with immune checkpoint inhibitors

Agata Prokopiuk; Agnieszka Socha; Emilia Babula; Agata Kornacka; Katarzyna Kołodziejczyk; Tomasz Dzierżanowski

doi:10.5114/pm.2024.142623

eISSN: 2081-2833
ISSN: 2081-0016

Medycyna Paliatywna/Palliative Medicine

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abstract:

Review paper

Diagnosis and surveillance of cardiovascular complications after treatment with immune checkpoint inhibitors

Agata Prokopiuk

¹

,

Agnieszka Socha

¹

,

Emilia Babula

¹

,

Agata Kornacka

¹

,

Katarzyna Kołodziejczyk

¹

,

Tomasz Dzierżanowski

^{1, 2}

Klinika Medycyny Paliatywnej, Warszawski Uniwersytet Medyczny, Warszawa, Polska
Caritas Diecezji Warszawsko-Praskiej, Warszawa, Polska

Medycyna Paliatywna 2024; 16(4)

DOI: https://doi.org/10.5114/pm.2024.142623

Online publish date: 2024/08/29

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Immune checkpoint inhibitors are drugs used with increasing frequency in anticancer therapy. Cardiovascular complications are rare after their use, but they can be fatal. They can manifest as arrhythmias, myocarditis, pericarditis, left ventricular failure, takotsubo cardiomyopathy, or acute coronary syndrome. Depending on the clinical form of cardiotoxicity, various methods are used for diagnosis, including determination of cardiac and non-cardiac biomarkers, and the presence of characteristic changes on electrocardiography, transthoracic echocardiography, or cardiac magnetic resonance imaging (MRI). Surveillance involves capturing patients at risk and performing routine tests, which include a general cardiovascular evaluation, ECG, transthoracic echocardiography, and determination of cardiac troponins and natriuretic peptides. Recent publications point to the potential value of markers such as high-sensitivity troponins, microRNA, C-reactive protein, neutrophil-to-lymphocyte ratio, neutrophil-to-eosinophilia ratio, global longitudinal strain, and myocardial strain visible on echocardiography and cardiac MRI. The goal is to accelerate the detection of cardiac complications after immune checkpoint inhibitors and reduce mortality.

keywords:

Diagnosis and surveillance of cardiovascular complications after treatment with immune checkpoint inhibitors

Agata Prokopiuk 1 , Agnieszka Socha 1 , Emilia Babula 1 , Agata Kornacka 1 , Katarzyna Kołodziejczyk 1 , Tomasz Dzierżanowski 1, 2

cardiotoxicity, immune checkpoint inhibitors, ICI, cardiac adverse events, CAE

Agata Prokopiuk

¹

,

Agnieszka Socha

¹

,

Emilia Babula

¹

,

Agata Kornacka

¹

,

Katarzyna Kołodziejczyk

¹

,

Tomasz Dzierżanowski

^{1, 2}