Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society

Agnieszka Żebrowska; Elżbieta Waszczykowska; Cezary Kowalewski; Katarzyna Woźniak; Małgorzata Olszewska; Waldemar Placek; Rafał Czajkowski; Jacek Szepietowski; Rafał Białynicki-Birula; Marian Dmochowski

doi:10.5114/dr.2016.59130

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2016
vol. 103

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abstract:

Special paper

Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society

Agnieszka Żebrowska

,

Elżbieta Waszczykowska

,

Cezary Kowalewski

,

Katarzyna Woźniak

,

Małgorzata Olszewska

,

Waldemar Placek

,

Rafał Czajkowski

,

Jacek Szepietowski

,

Rafał Białynicki-Birula

,

Marian Dmochowski

Przegl Dermatol 2016, 103, 95–101

DOI: https://doi.org/10.5114/dr.2016.59130

Online publish date: 2016/05/03

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AMA

Żebrowska A, Waszczykowska E, Kowalewski C, et al. Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society. Dermatology Review/Przegląd Dermatologiczny. 2016;103(2):95-101. doi:10.5114/dr.2016.59130.

APA

Żebrowska, A., Waszczykowska, E., Kowalewski, C., Woźniak, K., Olszewska, M.,  & Placek, W. et al. (2016). Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society. Dermatology Review/Przegląd Dermatologiczny, 103(2), 95-101. https://doi.org/10.5114/dr.2016.59130

Chicago

Żebrowska, Agnieszka, Elżbieta Waszczykowska, Cezary Kowalewski, Katarzyna Woźniak, Małgorzata Olszewska, Waldemar Placek,  and Rafał Czajkowski et al. 2016. "Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society". Dermatology Review/Przegląd Dermatologiczny 103 (2): 95-101. doi:10.5114/dr.2016.59130.

Harvard

Żebrowska, A., Waszczykowska, E., Kowalewski, C., Woźniak, K., Olszewska, M., Placek, W., Czajkowski, R., Szepietowski, J., Białynicki-Birula, R.,  and Dmochowski, M. (2016). Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society. Dermatology Review/Przegląd Dermatologiczny, 103(2), pp.95-101. https://doi.org/10.5114/dr.2016.59130

MLA

Żebrowska, Agnieszka et al. "Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society." Dermatology Review/Przegląd Dermatologiczny, vol. 103, no. 2, 2016, pp. 95-101. doi:10.5114/dr.2016.59130.

Vancouver

Żebrowska A, Waszczykowska E, Kowalewski C, Woźniak K, Olszewska M, Placek W et al. Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society. Dermatology Review/Przegląd Dermatologiczny. 2016;103(2):95-101. doi:10.5114/dr.2016.59130.

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Dermatitis herpetiformis (Duhring’s disease) is an autoimmune blistering dermatosis with a characteristic polymorphic, itchy rash. The autoimmune process against transglutaminases (TGs) is connected with asymptomatic or with mild symptoms of gluten-sensitive enteropathy (GSE). The diagnostic approach in DH should rely on clinical evaluation, direct immunofluorescence of perilesional skin and evaluation of serum IgA antibodies with ELISA with one substrate of four substrates from which to choose (tTG, eTG, npG, neo-tTG) using the ELISA method. In cases showing an equivocal clinical-laboratory picture such an approach should be broadened by performing histopathology of lesional skin and examining the HLA DQ2/DQ8 haplotype. Combined treatment with dapsone and a gluten-free diet in individualized combinations is generally the therapeutic method of choice in DH.

keywords:

Diagnostic and therapeutic guidelines of dermatitis herpetiformis (Duhring’s disease) – consensus of Polish Dermatological Society

Agnieszka Żebrowska , Elżbieta Waszczykowska , Cezary Kowalewski , Katarzyna Woźniak , Małgorzata Olszewska , Waldemar Placek , Rafał Czajkowski , Jacek Szepietowski , Rafał Białynicki-Birula , Marian Dmochowski

dermatitis herpetiformis, Duhring’s disease, IgA, transglutaminase, dapsone, gluten-free diet

Agnieszka Żebrowska

,

Elżbieta Waszczykowska

,

Cezary Kowalewski

,

Katarzyna Woźniak

,

Małgorzata Olszewska

,

Waldemar Placek

,

Rafał Czajkowski

,

Jacek Szepietowski

,

Rafał Białynicki-Birula

,

Marian Dmochowski