Dipeptidyl-aminopeptidase IV (CD26) in clinical diagnosis of cutaneous  T cell lymphomas

Małgorzata Sokołowska-Wojdyło; Agata Maciejewska-Radomska; Wioletta Barańska-Rybak; Andrzej Lewandowski; Agnieszka Cegielska; Jadwiga Roszkiewicz

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2010
vol. 97

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abstract:

Original paper

Dipeptidyl-aminopeptidase IV (CD26) in clinical diagnosis of cutaneous T cell lymphomas

Małgorzata Sokołowska-Wojdyło

,

Agata Maciejewska-Radomska

,

Wioletta Barańska-Rybak

,

Andrzej Lewandowski

,

Agnieszka Cegielska

,

Jadwiga Roszkiewicz

Przegl Dermatol 2010, 97, 74–78

Online publish date: 2010/04/30

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Introduction.Dipeptidyl-aminopeptidase IV, also known as CD26 antigen, plays a pivotal role in the pathogenesis of cutaneous T-cell lymphomas (CTCL). Nowadays it is believed that the loss of T-cell CD26 expression is a feature of circulating Sezary cells in peripheral blood.
Objective. Evaluation of the loss of T-cell CD26 expression as a diagnostic and prognostic marker in patients with CTCL and erythrodermias caused by other inflammatory dermatoses.
Material and methods. T-cell immunophenotyping by flow cytometry in 71 patients with CTCL, including Sezary syndrome, as well as with inflammatory skin diseases.
Results. High levels of CD4+/CD7–/CD26– cells and concomitant low T4:T8 ratio were seen in patients with Sezary syndrome and highly advanced stages of CTCL.
Conclusions. The loss of CD26 expression evaluated by flow cytometric immunophenotyping seems to be a useful method in dermatological practice for differential diagnosis of cutaneous T-cell lymphomas, especially Sezary syndrome. Probably the loss of T-cell CD26 antigen expression and high levels of Lutzner cells in peripheral blood in patients with inflammatory dermatoses may be a risk factor of CTCL development in future. It requires however further clinical observations.

keywords:

Dipeptidyl-aminopeptidase IV (CD26) in clinical diagnosis of cutaneous T cell lymphomas

Małgorzata Sokołowska-Wojdyło , Agata Maciejewska-Radomska , Wioletta Barańska-Rybak , Andrzej Lewandowski , Agnieszka Cegielska , Jadwiga Roszkiewicz

CD 26, dipeptidyl-aminopeptidase IV, Sezary syndrome, mycosis fungoides

Małgorzata Sokołowska-Wojdyło

,

Agata Maciejewska-Radomska

,

Wioletta Barańska-Rybak

,

Andrzej Lewandowski

,

Agnieszka Cegielska

,

Jadwiga Roszkiewicz