Drug hypersensitivity reactions and allergy in patients with mastocytosis

Justyna H. Czarny; Magdalena Lange; Marek B. Niedoszytko; Barbara Kwiecińska; Aleksandra Górska; Hanna Ługowska-Umer; Monika Sikorska; Roman Nowicki

doi:10.5114/dr.2017.66219

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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1/2017
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abstract:

Review paper

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Justyna H. Czarny

,

Magdalena Lange

,

Marek B. Niedoszytko

,

Barbara Kwiecińska

,

Aleksandra Górska

,

Hanna Ługowska-Umer

,

Monika Sikorska

,

Roman Nowicki

Przegl Dermatol 2017, 104, 22–30

DOI: https://doi.org/10.5114/dr.2017.66219

Online publish date: 2017/03/03

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Mastocytosis is a rare myeloproliferative disease caused by excessive proliferation and accumulation of mast cells in the skin and internal organs. The most common variant of mastocytosis in children is cutaneous mastocytosis. Systemic mastocytosis dominates in adults. Both CM and SM patients suffer from mast cell mediator-related symptoms such as itching, flushing, hypotension, abdominal pain, diarrhea, headache and anaphylaxis. The prevalence of anaphylaxis in patients with mastocytosis has been estimated to be about 50% in adults and about 9% in children. Anaphylaxis may be caused by many triggers including hymenoptera sting, drugs, physical factors, exercise, infections, alcohol, some food types and allergens. Drugs which may provoke anaphylaxis include nonsteroidal anti-inflammatory drugs, antibiotics, opioids, contrast media and muscle relaxants. Appropriate preparation of a patient for medical procedures and long-term prophylaxis allow one to reduce the risk of anaphylaxis in patients with mastocytosis.

keywords:

Drug hypersensitivity reactions and allergy in patients with mastocytosis

Justyna H. Czarny , Magdalena Lange , Marek B. Niedoszytko , Barbara Kwiecińska , Aleksandra Górska , Hanna Ługowska-Umer , Monika Sikorska , Roman Nowicki

drugs, prophylaxis, mastocytosis, anaphylaxis

Justyna H. Czarny

,

Magdalena Lange

,

Marek B. Niedoszytko

,

Barbara Kwiecińska

,

Aleksandra Górska

,

Hanna Ługowska-Umer

,

Monika Sikorska

,

Roman Nowicki