EBV-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large B-cell lymphoma of the central nervous system

Haoliang Xu; Julia Rewerska; Nathan Aardsma; Konstantin Slavin; Tibor Valyi-Nagy; Hongyu Ni

doi:10.5114/fn.2017.70487

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2017
vol. 55

Send email

Copy url:

abstract:

Case report

EBV-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large B-cell lymphoma of the central nervous system

Haoliang Xu

,

Julia Rewerska

,

Nathan Aardsma

,

Konstantin Slavin

,

Tibor Valyi-Nagy

,

Hongyu Ni

Folia Neuropathol 2017; 55 (3): 221-226

DOI: https://doi.org/10.5114/fn.2017.70487

Online publish date: 2017/09/30

View full text Get citation

PlumX metrics:

Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare complication with inferior survival outcomes in solid organ transplant patients. It represents approximately 7-15% of all PTLD patients. Because of the rarity of this disease, the diagnosis of PCNS-PTLD is often challenging, and the optimal therapy has not been established. We report a case of a renal transplant patient who initially presented with acute altered neurological function, an enhancing mass lesion of the brain on magnetic resonance imaging (MRI), and nonspecific reactive histopathological changes on brain biopsy. The lesion was self-limited and spontaneously resolved without medical treatment for PTLD. Six months later, surveillance MRI revealed recurrence of the brain lesion. The biopsy showed morphologic changes consistent with Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma. The patient responded well to reduction of immunosuppression and treatment with a single-agent regimen of rituximab. This is an unusual case of PCNS-PTLD with an initial presentation resembling a self-limited reactive lesion.

keywords:

EBV-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large B-cell lymphoma of the central nervous system

Haoliang Xu , Julia Rewerska , Nathan Aardsma , Konstantin Slavin , Tibor Valyi-Nagy , Hongyu Ni

post-transplant lymphoproliferative disorder, Epstein-Barr virus, large B-cell lymphoma, central nervous system

Haoliang Xu

,

Julia Rewerska

,

Nathan Aardsma

,

Konstantin Slavin

,

Tibor Valyi-Nagy

,

Hongyu Ni