eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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1/2024
vol. 21
 
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abstract:
Original paper

Effectiveness of autologous fibrin glue in preventing post-thoracotomy air leaks: a randomized controlled trial

Fariba Zabihi
1
,
Ali Mehri
2
,
Ghazale Ahmadi
2
,
Daryoush Hamidi Alamdari
3
,
Mona Kabiri
4
,
Azam Amirianfar
2
,
Reza Rezaei
5

  1. Department of General Surgery, Mashhad University of Medical Sciences, Mashhad, Iran
  2. Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  3. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  5. Department of Thoracic Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Kardiochirurgia i Torakochirurgia Polska 2024; 21 (1): 15-18
DOI: https://doi.org/10.5114/kitp.2024.138579
Online publish date: 2024/03/30
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Introduction
Post-thoracotomy air leaks remain a significant challenge in thoracic surgery.

Aim
This randomized controlled trial assessed the efficacy of autologous fibrin glue in reducing air leaks following thoracotomy procedures.

Material and methods
Conducted as a single-center, single-blind, randomized clinical trial, the study enrolled adult patients undergoing lung resection or decortication at a thoracic surgery clinic. Participants were randomly assigned to either the intervention group, receiving autologous fibrin glue application during surgery, or the control group, undergoing standard surgical procedures without glue application. Key inclusion criteria were adult patients undergoing elective thoracotomy for lung resection or decortication, while exclusion criteria included patients with severe comorbidities or contraindications to fibrin glue.

Results
A total of 40 patients were enrolled and randomized equally to the two groups. The group treated with autologous fibrin glue demonstrated a significant reduction in the duration of air leakage and chest tube drainage, along with a shorter hospital stay, compared to the control group. There were no statistically significant differences in postoperative complications between the groups.

Conclusions
The application of autologous fibrin glue during thoracotomy procedures significantly reduces postoperative air leaks and hospitalization duration without increasing complication rates. This finding suggests a beneficial role of fibrin glue in thoracic procedures requiring lung resection or decortication.

keywords:

The application of autologous fibrin glue during thoracotomy procedures significantly reduces postoperative air leaks and hospitalization duration without increasing complication rates This finding suggests a beneficial role of fibrin glue in thoracic procedures requiring lung resection or decortication
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