eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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6/2009
vol. 4
 
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abstract:
Original paper

Evaluation of the prognostic usefulness of 420C/T, 750A/T, -857C/T polymorphisms in the TNF-α gene among Polish patients with Crohn’s disease - original paper

Ludwika Jakubowska-Burek
,
Marcin A. Kucharski
,
Marta Kaczmarek
,
Justyna Hoppe-Gołębiewska
,
Oliwia Zakerska
,
Krzysztof Linke
,
Ryszard Słomski
,
Michał Drews
,
Ryszard Marciniak
,
Agnieszka Dobrowolska-Zachwieja

Przegląd Gastroenterologiczny 2009; 4 (6): 298-301
Online publish date: 2009/12/22
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Introduction: Crohn’s disease (CD), together with ulcerative colitis (UC), belongs to inflammatory bowel diseases (IBD). The aetiology of CD is still unknown but it is suspected that genetic, environmental and immunological factors play a major role in the background of CD. One of the genes investigated in the field of Crohn’s pathogenesis is TNF-α (tumor necrosis factor a).

Aim: To analyze three single nucleotide polymorphisms (SNP): two of them in the gene sequence and one in the promoter region (420C/T, 750A/T, -857C/T).

Material and methods: The investigated group consisted of 96 Polish patients with CD. Sequential analysis was performed using the pyrosequencing method.

Results: It was found that none of the three polymorphisms chosen for this analysis showed any differences among Polish patients with CD.

Conclusions: Polymorphisms 420C/T, 750A/T and -857C/T do not differentiate patients with CD and cannot be used for prognostics in the Polish population.
keywords:

Crohn’s disease, polymorphisms, pyrosequencing, TNF-α gene
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