Factors influencing death in COVID-19 patients treated  in the ICU: a single-centre, cross-sectional study

Izabela Kokoszka-Bargieł; Paweł Cyprys; Patryk Madeja; Katarzyna Rutkowska; Marta Wajda-Pokrontka; Jarosław Madowicz; Piotr Knapik

doi:10.5114/ait.2022.116231

eISSN: 1731-2531
ISSN: 1642-5758

Anaesthesiology Intensive Therapy

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Open access

Journal integrated with

2/2022
vol. 54

Send email

Copy url:

abstract:

Original paper

Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study

Izabela Kokoszka-Bargieł

¹

,

Paweł Cyprys

²

,

Patryk Madeja

¹

,

Katarzyna Rutkowska

²

,

Marta Wajda-Pokrontka

²

,

Jarosław Madowicz

^{3, 4}

,

Piotr Knapik

²

Department of Anesthesiology and Intensive Therapy, Provincial Specialist Hospital, Tychy, Poland
Department of Anesthesiology and Intensive Therapy, Silesian Centre for Heart Diseases in Zabrze, Medical University of Silesia, Poland
Medical Director, Provincial Specialist Hospital, Tychy, Poland
Department of Health Sciences, Higher School of Strategic Planning, Dąbrowa Górnicza, Poland

Anaesthesiol Intensive Ther 2022; 54, 2: 132–140

DOI: https://doi.org/10.5114/ait.2022.116231

Online publish date: 2022/06/13

View full text Get citation

PlumX metrics:

Background
This single-centre study investigated factors influencing death in coronavirus disease 2019 (COVID-19) patients treated in an intensive care unit (ICU).

Methods
Data of 113 consecutive patients with a severe form of COVID-19 infection, who completed their ICU stay in a large COVID-19-dedicated hospital in the Silesian Region of Poland during one year of the pandemic (between 10 March, 2020 and 10 March, 2021), were reviewed. Comprehensive comparison of all available ICU pre-admission, admission and treatment variables was performed. Variables that independently influenced ICU death were identified.

Results
ICU mortality in the whole group was 64.6%. Mean age was higher in non-survivors (64.6 ± 9.5 vs. 60.0 ± 12.8 years, P = 0.036), but the distribution of sex and body mass index was similar in both groups. Non-survivors had a marginally higher mean Charlson Comorbidity Index (5.9 ± 3.6 vs. 4.5 ± 4.1 points, P = 0.063), and significantly higher mean Clinical Frailty Score (4.8 ± 1.5 vs. 3.9 ± 1.4 points, P = 0.004), admission APACHE II score (22.9 ± 7.9 vs. 19.1 ± 7.8 points, P = 0.017) and SAPS II score (62.1 ± 18.1 vs. 54.0 ± 16.7 points, P = 0.023). Factors that independently influenced ICU death were limited to: admission total protein < 50 g L–1 (OR = 11.5, P = 0.002), procalcitonin level > 2.0 ng mL–1 (OR = 11.3, P = 0.026) and lactate level > 2.0 mmol L–1 (OR = 4.2, P = 0.003) as well as Clinical Frailty Score ≥ 5 points (OR = 3.1, P = 0.021).

Conclusions
The presence of low total protein, frailty and increased procalcitonin and lactate levels at ICU admission are associated with ICU death in patients with severe COVID-19 infection.

keywords:

Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study

Izabela Kokoszka-Bargieł 1 , Paweł Cyprys 2 , Patryk Madeja 1 , Katarzyna Rutkowska 2 , Marta Wajda-Pokrontka 2 , Jarosław Madowicz 3, 4 , Piotr Knapik 2

COVID-19, comorbidities, intensive care unit, mortality

Izabela Kokoszka-Bargieł

¹

,

Paweł Cyprys

²

,

Patryk Madeja

¹

,

Katarzyna Rutkowska

²

,

Marta Wajda-Pokrontka

²

,

Jarosław Madowicz

^{3, 4}

,

Piotr Knapik

²