Felty’s syndrome and T-cell large granular lymphocyte leukaemia  – similarities and differences

Monika Prochorec-Sobieszek; Teresa Wagner; Renata K. Maryniak

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2007
vol. 45

Send email

Copy url:

abstract:

Felty’s syndrome and T-cell large granular lymphocyte leukaemia – similarities and differences

Monika Prochorec-Sobieszek

,

Teresa Wagner

,

Renata K. Maryniak

Reumatologia 2007; 45, 2: 85–91

Online publish date: 2007/04/25

View full text Get citation

Recent studies suggest that Felty’s syndrome (FS) and T-cell large granular lymphocyte leukaemia (T-LGL) are related disorders that appear to share some pathogenetic mechanisms and clinical features: T-cell large granular lymphocytosis, immune-mediated neutrophil destruction resulting in neutropenia, variable splenomegaly and arthritis. FS is characterized by severe articular and extra-articular manifestations of rheumatoid arthritis (RA), neutropenia and splenomegaly, and in 30% of patients FS is associated with T-cell large granular lymphocytosis. On the other hand, T-LGL presents with monoclonal infiltration of T large granular lymphocytes in the bone marrow and spleen, neutropenia and splenomegaly, and in 25-35% patients it is associated with RA. The article reviews pathogenetic, histopathological, immunogenetic and clinical relations between these two diseases.

keywords:

Felty’s syndrome, T-cell large granular lymphocyte leukaemia

EVENTS/KONFERENCJE

BOOKS/KSIĄŻKI

Felty’s syndrome and T-cell large granular lymphocyte leukaemia – similarities and differences

Monika Prochorec-Sobieszek , Teresa Wagner , Renata K. Maryniak

Felty’s syndrome, T-cell large granular lymphocyte leukaemia

Monika Prochorec-Sobieszek

,

Teresa Wagner

,

Renata K. Maryniak