eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2020
vol. 45
 
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abstract:
Clinical immunology

Genetic variants of SERPING1 gene in Polish patients with hereditary angioedema due to C1 inhibitor deficiency

Krystyna Obtułowicz
1
,
Teofila Książek
2
,
Anna Bogdali
1
,
Wojciech Dyga
1
,
Ewa Czarnobilska
1
,
Aldona Juchacz
3

  1. Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland
  2. Department of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland
  3. Greater Poland Center of Pulmonology and Thoracic Surgery, Poznan, Poland
Cent Eur J Immunol 2020; 45 (3): 301-309
DOI: https://doi.org/10.5114/ceji.2020.101252
Online publish date: 2020/11/01
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Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) type I and II is a rare and life-threatening disease caused by SERPING1 gene mutations. Previous genetic studies indicated a wide spectrum of disease-associated variants in the SERPING1 gene and often lack of correlation with patient’s phenotypes. The aim of this study was to evaluate the presence, type, and localization of mutations in the SERPING1 gene in 41 Polish patients with C1-INH-HAE and their relation with case/family history, type of C1-INH-HAE, fC1-INH, age of onset, and disease severity. Sanger sequencing and MLPA method were used for detection of disease-associated variants. In 34 (82.9%) patients, mutations located in various regions of SERPING1 gene were revealed. The detected alterations in patients with C1-INH-HAE type I differed and were positioned in various exons/introns of the SERPING1 gene. The most frequent disease-associated variants appeared in exon 3 (especially in type I) and in exon 8 (type I and II). Out of 20 different disease-causing variants, 9 were not previously described. We did not find any relation between the type and location of the mutations and no type of features included in phenotype evaluation of the patients, such as case and family history, type of C1-INH-HAE, age of onset, biochemical parameters, or severity of disease.
keywords:

hereditary angioedema, C1-inhibitor, SERPING1, disease-associated variants
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