Genetics of psoriasis – from serological studies of human leukocyte antigens to whole genome
association studies</i>

Aneta Szczerkowska-Dobosz; Krzysztof Rębała

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2011
vol. 98

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abstract:

Special paper

Genetics of psoriasis – from serological studies of human leukocyte antigens to whole genome association studies

Aneta Szczerkowska-Dobosz

,

Krzysztof Rębała

Przegl Dermatol 2011, 98, 377–383

Online publish date: 2011/11/14

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Psoriasis is a complex disease with multifactorial mode of inheritance, which means that its clinical manifestations depend upon multiple genes interacting with environmental agents. The major genetic factor responsible for 35-50% susceptibility for early psoriasis in the Caucasian population, HLA-Cw*06, is located within the major histocompatibility complex (MHC) on the sixth chromosome. Whole genome association studies, the newest research trend, revealed three genetic, non-MHC related pathways connected with psoriasis susceptibility: Th17, Th2 and NF-kB-dependent. These genes are responsible for inflammation, epidermal proliferation and epidermal barrier function in psoriasis.

keywords:

Genetics of psoriasis – from serological studies of human leukocyte antigens to whole genome association studies

Aneta Szczerkowska-Dobosz , Krzysztof Rębała

EDC, GWAS, psoriasis, allele HLA-Cw*06, MHC

Aneta Szczerkowska-Dobosz

,

Krzysztof Rębała

EDC, GWAS, psoriasis, allele HLA-Cw06*, MHC