eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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1/2019
vol. 5
 
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abstract:
Original paper

Glutathione peroxidase and malondialdehyde in children with chronic hepatitis C

Mohammed Ahmed Khedr
1
,
Hanaa Ahmed El-Araby
1
,
Hatem Abdel-Sattar Konsowa
1
,
Samia Salem Sokar
2
,
Mohammed Fathy Mahmoud
1
,
Nermin Mohammed Adawy
1
,
Haidy Mohammed Zakaria
3

  1. Department of Pediatric Hepatology, Gastroenterology and Nutrition, National Liver Institute, Menoufia University, Shebin El-koom, Menoufia, Egypt
  2. Pharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Egypt
  3. Pediatric Department, Quesna Central Hospital, Ministry of Health, Menoufia, Egypt
Clin Exp HEPATOL 2019; 5, 1: 81–87
DOI: https://doi.org/10.5114/ceh.2019.83161
Online publish date: 2019/03/01
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Aim of the study
We aimed to assess oxidative stress factors, glutathione peroxidase (GPX) and malondialdehyde (MDA) in children with chronic hepatitis C (CHC) and their relation to treatment response.

Material and methods
The study included 50 children with chronic hepatitis C virus (HCV) before treatment (naïve HCV), 25 children responders to HCV treatment, 25 children non-responders to HCV treatment and 25 healthy controls. All patients and controls were subjected to GPX and MDA measurement by enzyme-linked immunosorbent assay.

Results
The average GPX activity in erythrocytes of naïve CHC patients was 29.2 ±10.3 mU/ml. It was statistically significantly lower than the average activity of GPX in erythrocytes of the healthy control group (47.3 ±5.2 mU/ml) (p < 0.05). The average GPX activity in erythrocytes of the responder group was 34.93 ±3.17 mU/ml. It was statistically significantly higher than the average activity of GPX in erythrocytes of the non-responder group (11.7 ±4.2 mU/ml) (p < 0.05). Plasma MDA was significantly higher in naïve CHC patients than in healthy controls (9.7 ±3.7 nmol/ml vs. 3 ±1.1 nmol/ml, p < 0.0001). Furthermore, plasma MDA concentration was significantly decreased in the responder group (5.36 ±0.7 nmol/ml) and elevated in the non-responder group (16.05 ±2.9 nmol/ml).

Conclusions
Lower pretreatment levels of GPX and higher MDA level might be markers of oxidative stress occurring in HCV patients. Reversal of changes of these levels with completion of the treatment may indicate a correlation between oxidative stress and the viral pathogenesis.

keywords:

malondialdehyde, glutathione peroxidase, hepatitis C virus
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