Green tea extract prevents the development of nonalcoholic liver steatosis in rats fed a high-fat diet

Dominika Karolczak; Monika Seget; Joanna Bajerska; Agata Błaszczyk; Sławomira Drzymała-Czyż; Jarosław Walkowiak; Andrzej Marszałek

doi:10.5114/pjp.2019.93132

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2019
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abstract:

Original paper

Green tea extract prevents the development of nonalcoholic liver steatosis in rats fed a high-fat diet

Dominika Karolczak

¹

,

Monika Seget

¹

,

Joanna Bajerska

²

,

Agata Błaszczyk

¹

,

Sławomira Drzymała-Czyż

³

,

Jarosław Walkowiak

³

,

Andrzej Marszałek

^{4, 5}

Electron Microscopy Laboratory, Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, Poland
Institute of Human Nutrition and Dietetics, Poznañ University of Life Sciences, Poland
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Department of Oncologic Pathology and Prophylaxis, Poznan University of Medical Sciences, Greater Poland Cancer Center, Poznan, Poland
Chair and Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Pol J Pat hol 2019; 70 (4): 295-303

DOI: https://doi.org/10.5114/pjp.2019.93132

Online publish date: 2020/03/06

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Green tea contains many polyphenolic constitutes, which might prevent non-alcoholic fatty liver disease (NAFLD). We aimed to investigate whether green tea extract (GTE) given at doses reflecting habitual consumption of green tea beverages prevents development of NAFLD in rats fed a high-fat diet (HFD).

Twenty-four male Wistar rats were randomly divided into four equal groups (two study and two control groups). The study groups received a HFD (approximately 50% energy from fat), enriched with 1.1% and 2.0% GTE, respectively, for a total of 56 days. The control groups were fed a HFD alone and normal standardised diet (low-fat diet), respectively, for the same period of time.

The percentage of hepatocytes affected by steatosis in the HFD group (median [1st-3rd quartile]: 25% [12-34%]) was higher (p < 0.033 and p < 0.050, respectively) than in the HFD-2.0%GTE group (9% [3-18%]) and normal diet group (10% [5-18%]). No significant differences were observed for the group consuming HFD-1.1%GTE, in which intermediate results were observed (15% [4-30%]).

This finding points towards the hepatoprotective potential of GTE in preventing dietary-induced liver steatosis. In view of the increasing incidence of overweight and obesity a simple and cheap dietary modification, such as GTE supplementation, could prove to be useful clinically.

keywords:

Green tea extract prevents the development of nonalcoholic liver steatosis in rats fed a high-fat diet

Dominika Karolczak 1 , Monika Seget 1 , Joanna Bajerska 2 , Agata Błaszczyk 1 , Sławomira Drzymała-Czyż 3 , Jarosław Walkowiak 3 , Andrzej Marszałek 4, 5

catechins, epigallocatechin-3-gallate, EGCG, obesity, fatty liver

Dominika Karolczak

¹

,

Monika Seget

¹

,

Joanna Bajerska

²

,

Agata Błaszczyk

¹

,

Sławomira Drzymała-Czyż

³

,

Jarosław Walkowiak

³

,

Andrzej Marszałek

^{4, 5}