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ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
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1/2018
vol. 5
 
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Guidelines/recommendations

Hypersensitivity to biological drugs. Guidelines of the Section of Drug Hypersensitivity of the Polish Society of Allergology

Anna Bodzenta-Łukaszyk
,
Grażyna Bochenek
,
Grażyna Sławeta
,
Marita Nittner-Marszalska
,
Joanna Glück
,
Marek L. Kowalski
,
Joanna Makowska
,
Barbara Rymarczyk
,
Grzegorz Porębski

Alergologia Polska – Polish Journal of Allergology 2018; 5, 1: 45–50
DOI: https://doi.org/10.5114/pja.2018.74449
Online publish date: 2018/03/23
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Biological agents represent an emerging therapeutic option in current medicine. They are widely used in many clinical conditions including inflammatory and oncologic diseases. Although they are highly efficient in many cases, they also can produce significant adverse immunologic reactions due to hypersensitivity or their own biological activity. Here we present management strategies for hypersensitive reactions induced by biological agents. Skin testing is most common diagnostic tool for drug causality assessment. Desensitization protocols have been found to be safe and effective. Pharmacovigilance system and safety of biologic therapies require further extensive research.
keywords:

biological agents, drug hypersensitivity, adverse drug reactions, fusion proteins, monoclonal antibodies


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