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Folia Neuropathologica
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2/2022
vol. 60
 
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abstract:
Original paper

Identification of a miRNA biomarker for the large artery atherosclerosis subtype of acute ischemic stroke

Bo Zhou
1
,
Bo Li
2
,
Pin Feng
3
,
Xin Wang
4
,
He Gao
4
,
Lifang Xu
4
,
Tianyi Wang
5
,
Xiaoling Guo
1

  1. Department of Neurology, The 981st Hospital of the Chinese People’s Liberation Army, Chengde, China
  2. Department of Orthopaedics, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China
  3. Department of General Surgery, The 981st Hospital of the Chinese People’s Liberation Army, Chengde, China
  4. Chengde Medical University, Chengde, Hebei Province, China
  5. Department of Orthopaedics, The 981st Hospital of the Chinese People’s Liberation Army, Chengde, China
Folia Neuropathol 2022; 60 (2): 210-220
DOI: https://doi.org/10.5114/fn.2022.117248
Online publish date: 2022/06/30
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Aim of the study
To identify miRNA biomarkers of arterial atherosclerosis subtypes in acute ischemic stroke.

Material and methods
40 participants recruited in our hospital from October 2017 to January 2018. There were 12 patients with acute ischemic stroke (AIS), 13 patients with atherosclerosis (AS) and 15 healthy subjects. They were divided into the AIS group, AS group and healthy control (HC) group. The miRNA expression levels of the AIS group, AS group and HC group were measured by DNA microarray. Bioinformatics analysis was performed using the miRNA target prediction database.

Results
The expression of 3 miRNAs, miR-129-1-3p, miR-4312, miR-5196-3p, was significantly different between the AIS and AS/HC groups. Genes targeted by miR-129-1-3p were involved in 12 pathways, of which axon guidance, retrograde endocannabinoid signalling and sphingolipid signalling pathways were associated with axonal and synaptic function. miR-129-1-3p mimics significantly decreased cortical neurite length and Runx2 levels, while miR-129-1-3p inhibitors promoted neurite growth and increased Runx2 expression.

Conclusions
miR-129-1-3p may be a relevant biomarker for the diagnosis of stroke caused by large artery atherosclerosis and could represent a novel therapeutic target for stroke treatment.

keywords:

stroke, artery atherosclerosis, MiRNA, microarray analysis, runt-related transcription factor
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