Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells

Zhuo Zhang; Shu-Zhen Yang; You-Fu Qi; Yong Yin

doi:10.5114/fn.2021.108695

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2021
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abstract:

Original paper

Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells

Zhuo Zhang

¹

,

Shu-Zhen Yang

²

,

You-Fu Qi

³

,

Yong Yin

⁴

Neurology Department, Liaocheng Second People’s Hospital, Liaocheng, Shandong, China
The Second People’s Hospital of Shenxian County, Shenxian, Shandong, China
Department of Neurology, Ward 2, Linqing People’s Hospital, Linqing, Shandong, China
Department of Neurology, Ward 4, People’s Hospital of Pingyi County, Pingyi, Shandong, China

Folia Neuropathol 2021; 59 (3): 239-248

DOI: https://doi.org/10.5114/fn.2021.108695

Online publish date: 2021/10/05

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Increasing evidence highlights that microRNAs (miRNAs) drive glioma initiation and development. Nevertheless, the underlying role of miR-21-5p in glioma is elusive. Hence, we evaluated the underlying role of miR-21-5p in glioma progression. Microarray data analysis provided data indicating that the miR-21-5p level was elevated in glioma. Silenced miR-21-5p suppressed glioma cell growth and invasion. Additionally, our results disclosed that ten-eleven translocation 1 (TET1) was directly targeted by miR-21-5p. Furthermore, antagomir-21-5p restrained glioma cell growth in a xenograft tumour model. In rescue experiments, knockdown of TET1 neutralized miR-21-5p silence-mediated inhibitory function on glioma cell aggressiveness. Taken together, miR-21-5p exerted its carcinogenic effect in glioma cell growth and invasin by targeting TET1.

keywords:

Identification of miR-21-5p/TET1-negative regulation pair in the aggressiveness of glioma cells

Zhuo Zhang 1 , Shu-Zhen Yang 2 , You-Fu Qi 3 , Yong Yin 4

glioma, proliferation, invasion, MiR-21-5p, TET1

Zhuo Zhang

¹

,

Shu-Zhen Yang

²

,

You-Fu Qi

³

,

Yong Yin

⁴