Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions

Tobias Welponer; Matthias Brandlmaier; Bernd Feuerstein; Johann Wolfgang Bauer

doi:10.5114/ada.2021.106036

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2022
vol. 39

Send email

Copy url:

abstract:

Letter to the Editor

Identifying drug allergies by means of exposure testing – the frequency and nature of hypersensitivity reactions

Tobias Welponer

¹

,

Matthias Brandlmaier

¹

,

Bernd Feuerstein

²

,

Johann Wolfgang Bauer

¹

Department of Dermatology and Allergology, University Hospital of the Paracelsus Medical University Salzburg, Austria
Department of Dermatology, Landeskrankenhaus Feldkirch, Austria

Adv Dermatol Allergol 2022; XXXIX (3): 632-634

DOI: https://doi.org/10.5114/ada.2021.106036

Online publish date: 2021/11/01

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Welponer T, Brandlmaier M, Feuerstein B, Wolfgang Bauer J. Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(3):632-634. doi:10.5114/ada.2021.106036.

APA

Welponer, T., Brandlmaier, M., Feuerstein, B.,  & Wolfgang Bauer, J. (2022). Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(3), 632-634. https://doi.org/10.5114/ada.2021.106036

Chicago

Welponer, Tobias, Matthias Brandlmaier, Bernd Feuerstein,  and Johann Wolfgang Bauer. 2022. "Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (3): 632-634. doi:10.5114/ada.2021.106036.

Harvard

Welponer, T., Brandlmaier, M., Feuerstein, B.,  and Wolfgang Bauer, J. (2022). Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(3), pp.632-634. https://doi.org/10.5114/ada.2021.106036

MLA

Welponer, Tobias et al. "Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 3, 2022, pp. 632-634. doi:10.5114/ada.2021.106036.

Vancouver

Welponer T, Brandlmaier M, Feuerstein B, Wolfgang Bauer J. Identifying drug allergies by means of exposure testing –
the frequency and nature of hypersensitivity reactions. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(3):632-634. doi:10.5114/ada.2021.106036.

Drug hypersensitivity reactions are dose-independent, unpredictable, and immune-mediated type B adverse drug reactions (ADR) in patients sensitized to a certain drug [1]. The first signs appear within minutes to hours of drug intake, ranging from low-grade to possibly life-threatening anaphylactic symptoms; they can also appear several hours to days later in the form of exanthema [2]. An allergic reaction should be substantiated within 4 weeks to 6 months after the reaction, aiming to identify the trigger and assess the risk for subsequent reactions [3].

Clinical classification, based on the morphology and timing of the reaction, is necessary for correct diagnosis. In the case of distinct symptoms of hypersensitivity and unambiguous findings of validated skin (in vivo) and/or laboratory tests (in vitro), the assignment to a trigger may be considered sufficient [4]. However, skin and laboratory tests lack high sensitivity and frequently show false negative or non-significant results [5].

Identifying drug allergies by means of exposure testing – the frequency and nature of hypersensitivity reactions

Tobias Welponer 1 , Matthias Brandlmaier 1 , Bernd Feuerstein 2 , Johann Wolfgang Bauer 1

Tobias Welponer

¹

,

Matthias Brandlmaier

¹

,

Bernd Feuerstein

²

,

Johann Wolfgang Bauer

¹