Immunological abnormalities in lichen planus

Aleksandra Ostrowska; Anna Susło

doi:10.5114/dr.2022.120179

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2022
vol. 109

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abstract:

Review article

Immunological abnormalities in lichen planus

Aleksandra Ostrowska

^{1, 2}

,

Anna Susło

^{1, 3}

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland
Katedra i Klinika Dermatologiczna, Warszawski Uniwersytet Medyczny, Warszawa, Polska
Wolski Hospital Dr Anna Gostyñska, Warsaw, Poland
Szpital Wolski im. dr Anny Gostyñskiej, Warszawa, Polska
Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland
Centralny Szpital Kliniczny MSWiA, Warszawa, Polska

Dermatol Rev/Przegl Dermatol 2022, 109, 217-228

DOI: https://doi.org/10.5114/dr.2022.120179

Online publish date: 2022/10/21

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Lichen planus is a chronic disease associated with the occurrence of characteristic papular pruritic lesions. The most significant immunological markers of lichen planus are cytokines. Numerous publications showed changes in the serum level of tumor necrosis factor, interferon g, interleukins 2, 4, 6, 8, 10, 17 and 22. Early lichen planus is associated with a high number of macrophages, T cells, and dendritic cells, while advanced lichen planus with a high number of Treg cells. There is no single specific marker for lichen planus, but certain cytokine levels can be used as a prognostic factor for disease progression and as an indicator of treatment response. Analysis of the immune markers can help to define the disease stage and lichen planus subtype, but histopathology still remains a standard in lichen planus diagnosis.

keywords:

Immunological abnormalities in lichen planus

Aleksandra Ostrowska 1, 2 , Anna Susło 1, 3

cytokines, biomarkers, lichen planus, immunologic factors

Aleksandra Ostrowska

^{1, 2}

,

Anna Susło

^{1, 3}