eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2019
vol. 57
 
Share:
Send email
Share:
abstract:
Original paper

Immunomodulatory and neuroprotective mechanisms of Huangqi glycoprotein treatment in experimental autoimmune encephalomyelitis

Yanxia Xing
1
,
Binyu Liu
1
,
Yijin Zhao
1
,
Lihong Zhang
1
,
Rodolfo Thome
2
,
Huiqing Xue
3
,
Peijun Zhang
1
,
Cungen Ma
1

  1. Institute of Brain Science, Medical College, Shanxi Datong University, Datong, China
  2. Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States
  3. “2011” Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, China
Folia Neuropathol 2019; 57 (2): 117-128
DOI: https://doi.org/10.5114/fn.2019.85843
Online publish date: 2019/06/16
View full text Get citation
 
PlumX metrics:
Previous studies have shown that Huangqi glycoprotein (HQGP) has an anti-inflammatory effect in vitro, and suppressed experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis; however, the mechanism underlying its effect is largely unknown. In this manuscript we investigated the mechanisms by which HQGP protect mice from EAE. HQGP was extracted from Astragalus membranaceus and purified by anion-exchange and gel filtration chromatography. HQGP delayed disease onset, reduced disease severity and alleviated inflammation and demyelination in the central nervous system (CNS). Moreover, HQGP reduced the infiltration of pathogenic immune cells and increased the expression of microtubule-associated protein 2 (MAP-2) and neuronal nuclei (NeuN) in the CNS. HQGP treatment also reduced the expression of chemokines such as CCL2 and CCL5 and the production of tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, but increased the level of IL-10. These results demonstrate that HQGP suppressed EAE development by modulating the immune system and the infiltration of leukocytes to the CNS as well as promoting axon and neural repair.
keywords:

Huangqi glycoprotein, experimental autoimmune encephalomyelitis, immunocyte, chemokines, nerve repair
FEATURED PRODUCTS
BOOKS
• Wprowadzenie do neurologopedii Wydanie II zaktualizowane
EVENTS
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.