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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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6/2024
vol. 41
 
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abstract:
Original paper

Impact of ozone concentration on the treatment effectiveness of diabetic foot syndrome: a pilot single-centre study

Jarosław Pasek
1
,
Sebastian Szajkowski
2
,
Dominika Rokicka
3
,
Marta Wróbel
3
,
Valter Travagli
4
,
Grzegorz Cieślar
5

  1. Władysław Biegański Collegium Medicum, Jan Długosz University, Częstochowa, Poland
  2. Faculty of Medical and Social Sciences, Warsaw Medical Academy of Applied Sciences, Warsaw, Poland
  3. Department of Internal Diseases, Diabetology, and Cardiometabolic Diseases, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases in Zabrze, Poland
  4. Department of Biotechnology, Chemistry and Pharmacy, Siena, Italy
  5. Department of Internal Medicine, Angiology and Physical Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland
Adv Dermatol Allergol 2024; XLI (6): 626-633
DOI: https://doi.org/10.5114/ada.2024.145477
Online publish date: 2024/12/24
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Introduction:
Diabetic foot syndrome (DFS) a severe complication of diabetes which can result in ulcers, infections, or tissue damage in the feet.

Aim:
To compare the treatment effectiveness in patients with DFS using local O3 therapy depending on the O3 concentration.

Material and methods:
The study included 50 patients, 24 male and 26 female ones, in the age range between 39 and 84 years, with DFS. In group 1 (25 patients), 30 µg/ml doses of ozone were applied, and in group 2 (25 patients) doses of 60 µg/ml. A total of 30 local ozone therapy procedures, lasting 30 min each, were performed in both groups, in two sessions (15 procedures), with a 4-week break between sessions. The effectiveness of wound healing was evaluated by computerized planimetry, and pain intensity was assessed with the use of the VAS scale.

Results:
After treatment, a statistically significant reduction in the area of wounds and the intensity of pain was achieved in both groups. The median (IQR) wound size after treatment in group 1 was: 4.5 (4–5) cm2, and in group 2: 4 (3–4.5) cm2; (p = 0.027). The median (IQR) pain intensity (VAS) after treatment in group 1 was: 5 (4–5) points, and in group 2: 4 (3–4.5) points (p = 0.002).

Conclusions:
The use of a higher concentration ozone increased the effectiveness of the therapy in terms of reducing the wound surface area and alleviating the pain. Therefore, the possibility of using higher ozone concentrations in the treatment of diabetic foot syndrome is worth considering.

keywords:

dose, ozone concentration, diabetic foot ulcers, wound healing, computerized planimetry, pain intensity
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