Incidence and morphology of secondary TDP-43 proteinopathies: Part 1

Albert Acewicz; Tomasz Stępień; Paulina Felczak; Sylwia Tarka; Teresa Wierzba-Bobrowicz

doi:10.5114/fn.2022.120314

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2022
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abstract:

Review paper

Incidence and morphology of secondary TDP-43 proteinopathies: Part 1

Albert Acewicz

¹

,

Tomasz Stępień

¹

,

Paulina Felczak

¹

,

Sylwia Tarka

²

,

Teresa Wierzba-Bobrowicz

¹

Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
Department of Forensic Medicine, Medical University of Warsaw, Warsaw, Poland

Folia Neuropathol 2022; 60 (3): 267-276

DOI: https://doi.org/10.5114/fn.2022.120314

Online publish date: 2022/11/03

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Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role in the pathogenesis of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Growing body of evidence indicate that pathological TDP-43 inclusions frequently occur in the context of other distinctive hallmark pathologies, referred to as secondary

TDP-43 proteinopathies. Comorbid TDP-43 pathology is well-documented in several neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, multiple system atrophy, or progressive supranuclear palsy. It may also appear as a consequence of less obvious disease etiologies, i.e. post-traumatic (chronic traumatic encephalopathy), neoplastic (pilocytic astrocytoma), or post-infectious (post-encephalitic parkinsonism). The aim of the present review was to evaluate the incidence, morphology, and role of TDP-43 pathology in the secondary TDP-43 proteinopathies. This article (Part 1) discussed TDP-43 pathology in more common neurodegenerative diseases, including Alzheimer’s disease, Lewy body disease, Huntington’s disease, multiple system atrophy, corticobasal degeneration, and progressive supranuclear palsy. A follow-up article (Part 2) will describe abnormal TDP-43 changes in rare neurodegenerative diseases or neurological diseases with nondegenerative etiology.

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Incidence and morphology of secondary TDP-43 proteinopathies: Part 1

Albert Acewicz 1 , Tomasz Stępień 1 , Paulina Felczak 1 , Sylwia Tarka 2 , Teresa Wierzba-Bobrowicz 1

TDP-43, pathology, proteinopathy, neurodegenerative, morphology, incidence, comorbidity

Albert Acewicz

¹

,

Tomasz Stępień

¹

,

Paulina Felczak

¹

,

Sylwia Tarka

²

,

Teresa Wierzba-Bobrowicz

¹