Incretin mimetics and drugs increasing the level of endogenous incretins in the treatment of type 2 diabetes mellitus

Anna Czech

ISSN: 1505-8409

Przewodnik Lekarza/Guide for GPs

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2/2009
vol. 12

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abstract:

Incretin mimetics and drugs increasing the level of endogenous incretins in the treatment of type 2 diabetes mellitus

Anna Czech

Przew Lek 2009; 2: 48-53

Online publish date: 2009/07/21

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The term incretins relates to the following intestinal hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide). They are responsible for 50-60% of insulin secretion. In type 2 diabetes the secretion of these hormones is diminished. In order to treat such disorders in type 2 diabetes, analogues of GLP-1 acting analogously as endogenous GLP-1 and drugs inhibiting the activity of DPP-IV (dipeptidyl peptidase IV) are introduced. In the treatment of type 2 diabetes these drugs are used as a monotherapy or a combined therapy either with metformin or sulfonylureas.

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Incretin mimetics and drugs increasing the level of endogenous incretins in the treatment of type 2 diabetes mellitus

Anna Czech

type 2 diabetes, incretins, incretin mimetics