Infectious agents in the pathogenesis of rosacea

Dorota M. Mehrholz; Roman Nowicki; Wioletta M. Barańska-Rybak

doi:10.5114/dr.2016.61783

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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4/2016
vol. 103

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abstract:

Review paper

Infectious agents in the pathogenesis of rosacea

Dorota M. Mehrholz

,

Roman Nowicki

,

Wioletta M. Barańska-Rybak

Przegl Dermatol 2016, 103, 323–329

DOI: https://doi.org/10.5114/dr.2016.61783

Online publish date: 2016/09/01

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Acne rosacea is a chronic inflammatory skin disease that affects the face. The symptoms depend on the stage of the disease. The first stage is characterized by erythema and telangiectasia. This is followed by a papulopustular phase and a phymatous type in the final stages. An ocular type of rosacea is described in the literature as well. In the etiopathogenesis of papulo-pustular and ocular types of rosacea, inflammatory response modulation caused by microorganisms living on the skin play a key role. Binding of bacterial ligands with epidermal receptors leads to induction of the inflammatory cascade. This leads to vasodilation and white blood cell chemotaxis, which causes a change in the microenvironment of the skin that assists in microorganism proliferation. Microorganisms such as Demodex folliculorum, Bacillus oleronius, Staphylococcus epidermidis, Chlamydia pneumoniae and Helicobacter pylori play a crucial role in the pathogenesis of rosacea.

keywords:

Infectious agents in the pathogenesis of rosacea

Dorota M. Mehrholz , Roman Nowicki , Wioletta M. Barańska-Rybak

Helicobacter pylori, etiology, rosacea, Demodex folliculorum, Staphylococcus epidermidis

Dorota M. Mehrholz

,

Roman Nowicki

,

Wioletta M. Barańska-Rybak