eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2020
vol. 45
 
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abstract:
Clinical immunology

Inflammation-associated gene polymorphisms and clinical variables in the incidence and progression of retinopathy of prematurity

Dawid Szpecht
1
,
Anna Chmielarz-Czarnocińska
2
,
Janusz Gadzinowski
1
,
Agnieszka Seremak-Mrozikiewicz
3
,
Grażyna Kurzawińska
3
,
Marta Szymankiewicz
1
,
Krzysztof Drews
3
,
Anna Gotz-Więckowska
2

  1. Chair and Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland
  2. Chair and Department of Ophthalmology, Poznan University of Medical Sciences, Poznan, Poland
  3. Department of Perinatology and Women’s Diseases, Poznan University of Medical Sciences, Poznan, Poland
Cent Eur J Immunol 2020; 45 (3): 283-293
DOI: https://doi.org/10.5114/ceji.2020.94789
Online publish date: 2020/04/27
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Introduction
A growing body of evidence shows that genetics plays a vital role in the development and progression of retinopathy of prematurity (ROP). Perinatal inflammation is also considered an important risk factor of ROP. Therefore, understanding the interplay of genetics and susceptibility to inflammation might shed light on the pathogenesis of ROP and make its screening and treatment more effective in preventing visual impairment in premature infants.

Material and methods
This study investigated the correlation of inflammation-associated gene polymorphisms: IL-1b +3953 C>T, IL-1RN VNTR 86 bp, IL-6 -174 G>C, IL-6 -596 G>A, and TNF-a -308 G>A as well as demographic and clinical characteristics of ROP in preterm infants (n = 90).

Results
Our results demonstrate that IL-1RN rs2234663 1/1 genotype prevails in infants with ROP that regresses without intervention, when compared to those requiring laser photocoagulation/anti-VEGF injection (p = 0.031). Genotype 2/2 of IL-1RN occurs more frequently in children with severe ROP (28.6%) than in the group in which ROP regressed spontaneously (4.0%). The analysis revealed also differences between the genotypes of IL-1RN in ROP patients with intrauterine infection and in patients who had ROP without intrauterine infection; however, this was not statistically significant. Other studied polymorphisms were not associated with ROP development or its progression.

Conclusions
These results suggest that different genotypes of IL-1RN might have an impact on the course of ROP. Genotype 2/2 of IL-1RN gene may predispose to ROP progression.

keywords:

inflammation, polymorphism, laser photocoagulation, retinopathy of prematurity (ROP), ranibizumab injection
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