Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature

Faruk Guclu Pinarli; Aynur Oguz; Ceyda Karadeniz; Arzu Okur; Avni Sarac; Kemali Baykaner; Huseyin Bora; Aylar Poyraz

doi:10.5114/wo.2012.27333

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2012
vol. 16

Send email

Copy url:

abstract:

Original paper

Institutional experience of paediatric high-grade central nervous system tumours: An analysis of 74 patients and review of the literature

Faruk Guclu Pinarli

,

Aynur Oguz

,

Ceyda Karadeniz

,

Arzu Okur

,

Avni Sarac

,

Kemali Baykaner

,

Huseyin Bora

,

Aylar Poyraz

Wspolczesna Onkol 2012; 16 (1): 26–33

DOI: https://doi.org/10.5114/wo.2012.27333

Online publish date: 2012/02/29

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Pinarli F, Oguz A, Karadeniz C, et al. Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature. Contemporary Oncology/Współczesna Onkologia. 2012;16(1):26-33. doi:10.5114/wo.2012.27333.

APA

Pinarli, F., Oguz, A., Karadeniz, C., Okur, A., Sarac, A.,  & Baykaner, K. et al. (2012). Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature. Contemporary Oncology/Współczesna Onkologia, 16(1), 26-33. https://doi.org/10.5114/wo.2012.27333

Chicago

Pinarli, Faruk Guclu, Aynur Oguz, Ceyda Karadeniz, Arzu Okur, Avni Sarac, Kemali Baykaner,  and Huseyin Bora et al. 2012. "Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature". Contemporary Oncology/Współczesna Onkologia 16 (1): 26-33. doi:10.5114/wo.2012.27333.

Harvard

Pinarli, F., Oguz, A., Karadeniz, C., Okur, A., Sarac, A., Baykaner, K., Bora, H.,  and Poyraz, A. (2012). Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature. Contemporary Oncology/Współczesna Onkologia, 16(1), pp.26-33. https://doi.org/10.5114/wo.2012.27333

MLA

Pinarli, Faruk Guclu et al. "Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature." Contemporary Oncology/Współczesna Onkologia, vol. 16, no. 1, 2012, pp. 26-33. doi:10.5114/wo.2012.27333.

Vancouver

Pinarli F, Oguz A, Karadeniz C, Okur A, Sarac A, Baykaner K et al. Institutional experience of paediatric high-grade central nervous system  tumours: An analysis of 74 patients and review of the literature. Contemporary Oncology/Współczesna Onkologia. 2012;16(1):26-33. doi:10.5114/wo.2012.27333.

PlumX metrics:

Aim of the study: Although the survival for children with certain central nervous system (CNS) tumour types has improved through current surgical and adjuvant treatment modalities, the prognosis of many high-grade tumours remains poor despite aggressive treatment. The aim of this study is to analyse patients with high-grade brain tumours in our institution to determine the histopathology, clinical characteristics, treatment modalities, and survival.

Material and methods : A total of 74 patients with a diagnosis of high-grade brain tumour were analysed. There were a total of 31 patients with embryonal tumours, 27 patients with high-grade glial tumours, 12 patients with brain stem gliomas and 4 patients with other high-grade brain tumours.

Results : There were 48 (65%) boys and 26 (35%) girls (ratio: 1.85) with a median age of 99.7 months (range = 2-204 months). The median follow-up period was 19 months (range = 1-204 months). Tumour recurrence was observed in 38 patients (51.4%). The overall survival rate and event-free survival rate of our patients were 27% and 19.5%, respectively.

Conclusions : Pediatric high-grade CNS tumours have a very aggressive behaviour and a significant number of children eventually succumb to disease despite multimodal treatment. There is a need of more effective therapeutic approaches for these tumours with poor prognosis. The future improvement in childhood high-grade brain tumour management depends on a better understanding of the molecular genetics and biology of brain tumours.

keywords:

Institutional experience of paediatric high-grade central nervous system tumours: An analysis of 74 patients and review of the literature

Faruk Guclu Pinarli , Aynur Oguz , Ceyda Karadeniz , Arzu Okur , Avni Sarac , Kemali Baykaner , Huseyin Bora , Aylar Poyraz

CNS cancers, paediatric oncology, survival, chemotherapy, medulloblastoma, glioma

Faruk Guclu Pinarli

,

Aynur Oguz

,

Ceyda Karadeniz

,

Arzu Okur

,

Avni Sarac

,

Kemali Baykaner

,

Huseyin Bora

,

Aylar Poyraz