Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś; Michał Szczepański; Dorota Gliwicz; Maciej Dądalski; Daniel Kotlarz; Christofer Klein; Józef Ryżko; Piotr Socha

doi:10.5114/pg.2013.36336

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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3/2013
vol. 8

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abstract:

Case report

Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś

,

Michał Szczepański

,

Dorota Gliwicz

,

Maciej Dądalski

,

Daniel Kotlarz

,

Christofer Klein

,

Józef Ryżko

,

Piotr Socha

Prz Gastroenterol 2013; 8 (3): 202–205

DOI: https://doi.org/10.5114/pg.2013.36336

Online publish date: 2013/07/04

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AMA

Kierkuś J, Szczepański M, Gliwicz D, et al. Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2013;8(3):202-205. doi:10.5114/pg.2013.36336.

APA

Kierkuś, J., Szczepański, M., Gliwicz, D., Dądalski, M., Kotlarz, D.,  & Klein, C. et al. (2013). Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny, 8(3), 202-205. https://doi.org/10.5114/pg.2013.36336

Chicago

Kierkuś, Jarosław, Michał Szczepański, Dorota Gliwicz, Maciej Dądalski, Daniel Kotlarz, Christofer Klein,  and Józef Ryżko et al. 2013. "Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease". Gastroenterology Review/Przegląd Gastroenterologiczny 8 (3): 202-205. doi:10.5114/pg.2013.36336.

Harvard

Kierkuś, J., Szczepański, M., Gliwicz, D., Dądalski, M., Kotlarz, D., Klein, C., Ryżko, J.,  and Socha, P. (2013). Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny, 8(3), pp.202-205. https://doi.org/10.5114/pg.2013.36336

MLA

Kierkuś, Jarosław et al. "Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 8, no. 3, 2013, pp. 202-205. doi:10.5114/pg.2013.36336.

Vancouver

Kierkuś J, Szczepański M, Gliwicz D, Dądalski M, Kotlarz D, Klein C et al. Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2013;8(3):202-205. doi:10.5114/pg.2013.36336.

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Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition characterized by abdominal pain, diarrhoea, bleeding, and malabsorption. The disease is common in young people (children and young adults) yet it is rather rare in children younger than 2 years. A distinct phenotype of early onset IBD (EO-IBD) in infants and small children with severe intractable enterocolitis and greater tendency to develop colonic disease has been described. Recent work has demonstrated that EO-IBD with manifestation in the first months of life can be monogenic, resulting from mutations in interleukin-10 (IL-10) or its receptor and leading to a loss of IL-10 function. Allogeneic haematopoietic stem cell transplantation (HSCT) can be a successful treatment for those patients. We present here a case of a female IL-10R-deficient patient with severe EO-IBD who underwent HSCT.

keywords:

Interleukin-10 receptor deficiency in a Polish paediatric patient with early onset inflammatory bowel disease

Jarosław Kierkuś , Michał Szczepański , Dorota Gliwicz , Maciej Dądalski , Daniel Kotlarz , Christofer Klein , Józef Ryżko , Piotr Socha

inflammatory bowel diseases, children, interleukin-10

Jarosław Kierkuś

,

Michał Szczepański

,

Dorota Gliwicz

,

Maciej Dądalski

,

Daniel Kotlarz

,

Christofer Klein

,

Józef Ryżko

,

Piotr Socha