Interleukins 30 and 27 in psoriasis and inflammation

Marianna Majchrzycka; Joanna Wegner; Zygmunt Adamski; Dorota Jenerowicz

doi:10.5114/ada.2025.147548

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Interleukins 30 and 27 in psoriasis and inflammation

Marianna Majchrzycka

¹

,

Joanna Wegner

²

,

Zygmunt Adamski

¹

,

Dorota Jenerowicz

¹

Department of Dermatology, University Clinical Hospital, Poznan, Poland
Department of Dermatology, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Germany

Adv Dermatol Allergol

DOI: https://doi.org/10.5114/ada.2025.147548

Online publish date: 2025/02/09

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This review explores the roles of interleukin-30 (IL-30) and interleukin-27 (IL-27) in inflammation and autoimmune diseases, with a focus on psoriasis. The two coexisting cytokines should be analysed in conjunction as their actions are antagonistic in vivo. While IL-27 exhibits diverse anti-inflammatory mechanisms, the understanding of IL-30’s functions remains limited. Studies suggest that IL-27 may play a role in regulating psoriasis, but findings are inconsistent. IL-30 shows promise in mitigating psoriatic lesions and suppressing inflammatory responses. However, research on IL-30’s involvement in autoimmune diseases presents conflicting results. This article provides a literature review on the complex correlations between cytokines, their role in the pathogenesis of psoriasis, inflammation, carcinogenesis, and autoimmune diseases, and provides a detailed picture of the interplay between IL-27 and IL-30 to uncover novel therapeutic targets for psoriasis and other autoimmune conditions.

keywords:

Interleukins 30 and 27 in psoriasis and inflammation

Marianna Majchrzycka 1 , Joanna Wegner 2 , Zygmunt Adamski 1 , Dorota Jenerowicz 1

psoriasis, interleukin-27, interleukin-30

Marianna Majchrzycka

¹

,

Joanna Wegner

²

,

Zygmunt Adamski

¹

,

Dorota Jenerowicz

¹