1. Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007; 148: 32-46.
2.
Babolin C, Amedei A, Ozoliņš D, Žileviča A, D’Elios MM, de Bernard M. TpF1 from Treponema pallidum activates inflammasome and promotes the development of egulatory T cells. J Immunol 2011; 187: 1377-1384.
3.
Babaloo Z, Khajir Yeganeh R, Farhoodi M, Baradaran B, Bonyadi M, Aghebati L. Increased IL-17A but decreased IL-27 serum levels in patients with multiple sclerosis. Iran J Immunol 2013; 10: 47-54.
4.
Beale MA, Marks M, Cole MJ, Lee MK, Pitt R, Ruis C, Balla E, Crucitti T, Ewens M, Fernández-Naval C, Grankvist A. Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis. Nat Microbiol 2021; 6: 1549-1560.
5.
Bernardeschi C, Grange PA, Janier M, Gressier L, Dion PL, Benhaddou N, Bianchi A, Lassau F, Avril MF, Batteux F, Dupin N. Treponema pallidum induces systemic TH17 and TH1 cytokine responses. Eur J Dermatol 2012; 22: 797-798.
6.
Cai SN, Long J, Chen C, Wan G, Lun WH. Incidence of asymptomatic neurosyphilis in serofast Chinese syphilis patients. Sci Rep 2017; 7: 1-5.
7.
Castro R, Águas MJ, Batista T, Araújo C, Mansinho K, Pereira FD. Detection of Treponema pallidum sp. pallidum DNA in cerebrospinal fluid (CSF) by two PCR techniques. J Clin Lab Anal 2016; 30: 628-632.
8.
Castro R, Prieto ES, da Luz Martins Pereira F. Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests. J Clin Lab Anal 2008; 22: 257-261.
9.
Davis AP, Stern J, Tantalo L, Sahi S, Holte S, Dunaway S, Marra CM. How well do neurologic symptoms identify individuals with neurosyphilis? Clin Infect Dis 2018; 66: 363-367.
10.
Drago F, Merlo G, Ciccarese G, Agnoletti AF, Cozzani E, Rebora A, Parodi A. Changes in neurosyphilis presentation: a survey on 286 patients. J Eur Acad Dermatol Venereol 2016; 30: 1886-1900.
11.
Elmouden H, Louhab N, Kissani N. Medullary involvement in neurosyphilis: a report of 12 cases and a review of the literature. Spinal Cord Ser Cases 2019; 5: 1-9.
12.
Faucher JF, Ploy MC. Bacterial diseases of the nervous system. In: Neuroepidemiology in Tropical Health. Academic Press 2018; 247-267.
13.
Gayet-Ageron A, Sednaoui P, Lautenschlager S, Ferry T, ToutousTrellu L, Cavassini M, Yassir F, de Tejada BM, Emonet S, Combescure C, Schrenzel J. Use of Treponema pallidum PCR in testing of ulcers for diagnosis of primary syphilis. Emerg Infect Dis 2015; 21: 127.
14.
Ghanem KG, Ram S, Rice PA. The modern epidemic of syphilis. N Engl J Med 2020; 382: 845-854.
15.
Golden MR, Marra CM, Holmes KK. Update on syphilis: resurgence of an old problem. JAMA 2003; 290: 1510-1514.
16.
Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5: 521-531.
17.
Jaiswal AK, Jamal SB, Gabriel Rodrigues Gomes L, Profeta R, Sales-Campos H, Oliveira CJ, Figueira Aburjaile F, Tiwari S, Barh D, Silva MV, de Castro Soares S. Neuroinformatics insights towards multiple neurosyphilis complications. Venereology 2022; 1: 135-160.
18.
Kalliolias GD, Ivashkiv LB. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol 2008; 180: 6325-6333.
19.
Kenyon C, Lynen L, Florence E, Caluwaerts S, Vandenbruaene M,Apers L, Soentjens P, Van Esbroeck M, Bottieau E. Syphilis reinfections pose problems for syphilis diagnosis in Antwerp, Belgium–1992 to 2012. Euro Surveill 2014; 19: 20958.
20.
Khamaysi Z, Bergman R, Telman G, Goldsher D. Clinical and imaging findings in patients with neurosyphilis: a study of a cohort and review of the literature. Int J Dermatol 2014; 53: 812-819.
21.
Klein M, Angstwurm K, Esser S, Hahn K, Maschke M, Scheithauer S, Schoefer H, Sturzenegger M, Wildemann B, Weber J. German guidelines on the diagnosis and treatment of neurosyphilis. Neurol Res Pract 2020; 2: 1-9.
22.
Kordasti SY, Afzali B, Lim Z, Ingram W, Hayden J, Barber L, Matthews K, Chelliah R, Guinn B, Lombardi G, Farzaneh F. IL-17-producing CD4+ T cells, pro‐inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome. Br J Haematol 2009; 145: 64-72.
23.
Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J, Chang A, Zou W. Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol 2007; 178: 6730-6733.
24.
Lucas S, Ghilardi N, Li J, de Sauvage FJ. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. Proc Natl Acad Sci 2003; 100: 15047-15052.
25.
Lucas V, De Paepe A, Vanden Bossche S, Sven D. The great imitator: latent neurosyphilis presenting with uveitis and labyrinthitis. Acta Neurol Belg 2022; 1-3.
26.
Marks M, Lawrence D, Kositz C, Mabey D. Diagnostic performance of PCR assays for the diagnosis of neurosyphilis: a systematic review. Sex Trans Infect 2018; 94: 585-588.
27.
Marra CM, Maxwell CL, Smith SL, Lukehart SA, Rompalo AM, Eaton M, Stoner BP, Augenbraun M, Barker DE, Corbett JJ, Zajackowski M. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features.
28.
J Infect Dis 2004; 189: 369-376.
29.
Miyazaki Y, Inoue H, Matsumura M, Matsumoto K, Nakano T, Tsuda M, Hamano S, Yoshimura A, Yoshida H. Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice. J Immunol 2005; 175: 2401-2407.
30.
Montes de Oca M, de Labastida Rivera F, Winterford C, Frame TC, Ng SS, Amante FH, Edwards CL, Bukali L, Wang Y, Uzonna JE, Kuns RD. IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection. PLoS Pathog 2020; 16: e1008994.
31.
Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol 2007; 37: 1809-1816.
32.
Nieuwenburg SA, Zondag HC, Bruisten SM, Jongen VW, Schim van der Loeff MF, van Dam AP, de Vries HJ. Detection of Treponema pallidum DNA during early syphilis stages in peripheral blood, oropharynx, ano-rectum and urine as a proxy for transmissibility. Clin Infect Dis 2022; 75: 1054-1062.
33.
Nishiki S, Arima Y, Kanai M, Shimuta K, Nakayama SI, Ohnishi M. Epidemiology, molecular strain types, and macrolide resistance of Treponema pallidum in Japan, 2017–2018. J Infect Chemother 2020; 26: 1042-1047.
34.
Owaki T, Asakawa M, Morishima N, Hata K, Fukai F, Matsui M, Mizuguchi J, Yoshimoto T. A role for IL-27 in early regulation of Th1 differentiation. J Immunol 2005; 175: 2191-2200.
35.
Pastuszczak M, Gozdzialska A, Jakiela B, Obtulowicz A, Jaskiewicz J, Wojas-Pelc A. Robust pro-inflammatory immune response is associated with serological cure in patients with syphilis: an observational study. Sex Transm Infect 2017; 93: 11-14.
36.
Pastuszczak M, Jakiela B, Jaworek AK, Wypasek E, Zeman J, Wojas-Pelc A. Association of Interleukin-10 promoter polymorphisms with neurosyphilis. Hum Immunol 2015; 76: 469-472.
37.
Pastuszczak M, Jakiela B, Wielowieyska-Szybinska D, Jaworek AK, Zeman J, Wojas-Pelc A. Elevated cerebrospinal fluid interleukin-17A and interferon-g levels in early asymptomatic neurosyphilis. Sex Transm Dis 2013; 40: 808-812.
38.
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity 2002; 16: 779-790.
39.
Pinto M, Borges V, Antelo M, Pinheiro M, Nunes A, Azevedo J, Borrego MJ, Mendonca J, Carpinteiro D, Vieira L, Gomes JP. Genome-scale analysis of the non-cultivable Treponema pallidum reveals extensive within-patient genetic variation. Nat Microbiol 2016; 2: 16190.
40.
Ropper AH. Neurosyphilis. N Engl J Med 2019; 381: 1358-1363.
41.
Radolf JD, Deka RK, Anand A, Šmajs D, Norgard MV, Yang XF. Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen. Nat Rev Microbiol 2016; 14: 744-759.
42.
Shah BB, Lang AE. Acquired neurosyphilis presenting as movement disorders. Mov Disord 2012; 27: 690-695.
43.
Shang XJ, He CF, Tang B, Chang XL, Ci C, Sang H. Neuroimaging features, follow-up analyses, and comparisons between asymptomatic and symptomatic neurosyphilis. Dermatol Ther 2020; 10: 273-283.
44.
Sharma C, Nath K, Kumawat BL, Khandelwal D, Jain D. Erb’s paraplegia with primary optic atrophy: Unusual presentation of neurosyphilis: Case report and review of literature. Ann Indian Acad Neurol 2014; 17: 231-233.
45.
Skalnaya A, Fominykh V, Ivashchenko R, Averchenkov D, Grazhdantseva L, Frigo N, Negasheva E, Dolya O, Brylev L, Guekht A. Neurosyphilis in the modern era: Literature review and case series. J Clin Neurosci 2019; 69: 67-73.
46.
Stary G, Klein I, Brüggen MC, Kohlhofer S, Brunner PM, Spazierer D, Müllauer L, Petzelbauer P, Stingl G. Host defense mechanisms in secondary syphilitic lesions: A role for IFN-g-/IL-17-producing CD8+ T cells? Am J Pathol 2010; 177: 2421-2432.
47.
Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol 2007; 19: 281-286.
48.
Stumhofer JS, Hunter CA. Advances in understanding the anti-inflammatory properties of IL-27. Immunol Lett 2008; 117: 123-130.
49.
Tuddenham S, Ghanem KG. Neurosyphilis: knowledge gaps and controversies. Sex Transm Dis 2018; 45: 147.
50.
Wang C, Tian Y, Lei B, Xiao X, Ye Z, Li F, Kijlstra A, Yang P. Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci 2012; 53: 4668-4675.
51.
Wang C, Zhu L, Gao Z, Guan Z, Lu H, Shi M, Gao Y, Xu H, Yang XF, Zhou P. Increased interleukin-17 in peripheral blood and cerebrospinal fluid of neurosyphilis patients. PLoS Negl Trop Dis 2014; 8: e3004.
52.
Wraith DC. Anti‐cytokine vaccines and the immunotherapy of autoimmune diseases. Eur J Immunol 2006; 36: 2844-2848.
53.
Xie M, Li C, She Z, Wu F, Mao J, Hun M, Luo S, Wan W, Tian J, Wen C. Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro. Sci Rep 2022; 12: 13101.
54.
Zhao J, Ma J, Zhang X, Li Q, Yang X. Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance. Exp Ther Med 2016; 11: 2300-2304.
55.
Zhu A, Han H, Zhao H, Hu J, Jiang C, Xie F, Wang F. Increased frequencies of Th17 and Th22 cells in the peripheral blood of patients with secondary syphilis. FEMS Immunol Med Microbiol 2012; 66: 299-306.