Itopride as an element of the management of opioid-induced constipation – preliminary results of an observational study

Tomasz Dzierżanowski; Aleksandra Ciałkowska-Rysz

doi:10.5114/pm.2019.83842

eISSN: 2081-2833
ISSN: 2081-0016

Medycyna Paliatywna/Palliative Medicine

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abstract:

Original paper

Itopride as an element of the management of opioid-induced constipation – preliminary results of an observational study

Tomasz Dzierżanowski

¹

,

Aleksandra Ciałkowska-Rysz

²

Pracownia Medycyny Paliatywnej, Zakład Medycyny Społecznej i Zdrowia Publicznego, Warszawski Uniwersytet Medyczny
Pracownia Medycyny Paliatywnej, Katedra Onkologii, Uniwersytet Medyczny w Łodzi

Medycyna Paliatywna 2019; 11(1): 27–32

DOI: https://doi.org/10.5114/pm.2019.83842

Online publish date: 2019/03/25

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It is recommended that laxatives be prescribed for the prevention of opioid-induced constipation (OIC). This retrospective study aims to verify whether itopride, added to preventive OIC therapy, decreases the necessity of regular laxatives in the prevention of opioid-induced constipation in adult palliative care patients. Ninety-two patients met the inclusion criteria. All patients received, if needed, regular laxatives, oxycodone/naloxone (OXN), itopride 50 mg TID orally, or a combination of these drugs. All methods were similarly effective in the prevention of OIC. However, the necessity of laxatives decreased in groups where itopride was used, compared to control or OXN groups (p = 0.009). OXN did not decrease laxative use (p = 0.22). We conclude that adding itopride, but not oxycodone/naloxone, resulted in a decrease in the necessity of laxative use in the prevention of OIC. Taking into consideration the limitations of this study, a randomised controlled trial is necessary to confirm this finding.

keywords:

Itopride as an element of the management of opioid-induced constipation – preliminary results of an observational study

Tomasz Dzierżanowski 1 , Aleksandra Ciałkowska-Rysz 2

palliative care, constipation, prokinetics, itopride, oxycodone/naloxone

Tomasz Dzierżanowski

¹

,

Aleksandra Ciałkowska-Rysz

²