Kuru and D. Carleton Gajdusek: a close encounter

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ISSN: 1641-4640

Folia Neuropathologica

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2/2009
vol. 47

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abstract:

Kuru and D. Carleton Gajdusek: a close encounter

Folia Neuropathol 2009; 47 (2): 114-137

Online publish date: 2009/06/26

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Kuru, the first human transmissible spongiform encephalopathy, was transmitted to chimpanzees by D. Carleton Gajdusek (1923-2008). In this review, I briefly summarize the history of this seminal discovery alongside its epidemiology, clinical picture, neuropathology and molecular genetics. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease as well as the prediction that bovine spongiform encephalopathy would be transmitted to humans. It was one of the greatest discoveries in biomedical sciences of the 20th century.

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Kuru and D. Carleton Gajdusek: a close encounter

kuru, prion diseases, neuropathology, Carleton Gajdusek