1. Altamura S, Muckenthaler MU. Iron toxicity in diseases of aging: Alzheimer’s disease, Parkinson’s disease and atherosclerosis. J Alzheimers Dis 2009; 16: 879-895.
2.
Alzheimer’s Association. 2016 Alzheimer’s disease facts and figures. Alzheimers Dement 2016; 12: 459-509.
3.
Bao H, Gao M. Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3beta phosphorylation. Biochem Biophys Res Commun 2020; 521: 964-970.
4.
Bencze J, Morotz GM, Seo W, Bencs V, Kalman J, Miller CCJ, Hortobagyi T. Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration. Mol Brain 2018; 11: 20.
5.
Bencze J, Szarka M, Bencs V, Szabo RN, Modis LV, Aarsland D, Hortobagyi T. Lemur Tyrosine Kinase 2 (LMTK2) level inversely correlates with phospho-tau in neuropathological stages of Alzheimer’s disease. Brain Sci 2020; 10: 68.
6.
Bencze J, Szarka M, Bencs V, Szabo RN, Smajda M, Aarsland D, Hortobagyi T. Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer’s disease and neocortical Lewy body disease. Sci Rep 2019; 9: 17222.
7.
Chen Z, Zhong C. Oxidative stress in Alzheimer’s disease. Neurosci Bull 2014; 30: 271-281.
8.
Conti A, Majorini MT, Fontanella E, Bardelli A, Giacca M, Delia D, Mano M, Lecis D. Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members. Cancer Lett 2017; 389: 59-69.
9.
Crous-Bou M, Minguillon C, Gramunt N, Molinuevo JL. Alzheimer’s disease prevention: from risk factors to early intervention. Alzheimers Res Ther 2017; 9: 71.
10.
Dinkova-Kostova AT, Abramov AY. The emerging role of Nrf2 in mitochondrial function. Free Radic Biol Med 2015; 88: 179-188.
11.
Johnson JA, Johnson DA, Kraft AD, Calkins MJ, Jakel RJ, Vargas MR, Chen PC. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann N Y Acad Sci 2008; 1147: 61-69.
12.
Joshi G, Johnson JA. The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov 2012; 7: 218-229.
13.
Katzman R. The prevalence and malignancy of Alzheimer disease: a major killer. Alzheimers Dement 2008; 4: 378-380.
14.
Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Genes Cells 2004; 9: 219-232.
15.
Lee JM, Li J, Johnson DA, Stein TD, Kraft AD, Calkins MJ, Jakel RJ, Johnson JA. Nrf2, a multi-organ protector? FASEB J 2005; 19: 1061-1066.
16.
Lee JM, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 2003; 278: 37948-37956.
17.
Morotz GM, Glennon EB, Gomez-Suaga P, Lau DHW, Robinson ED, Sedlak E, Vagnoni A, Noble W, Miller CCJ. LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains. Acta Neuropathol Commun 2019; 7: 73.
18.
Obulesu M, Lakshmi MJ. Apoptosis in Alzheimer’s disease: an understanding of the physiology, pathology and therapeutic avenues. Neurochem Res 2014; 39: 2301-2312.
19.
Rui Q, Cao S, Wang X, Duan X, Iao X, Dong W, Fang Q, Zhang X, Xue Q. LMTK2 regulates inflammation in lipopolysaccharide-stimulated BV2 cells. Exp Ther Med 2021; 21: 219.
20.
Rushmore TH, Pickett CB. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J Biol Chem 1990; 265: 14648-14653.
21.
Wang X, Wang W, Li L, Perry G, Lee HG, Zhu X. Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease. Biochim Biophys Acta 2014; 1842: 1240-1247.
22.
Wilson RS, Segawa E, Boyle PA, Anagnos SE, Hizel LP, Bennett DA. The natural history of cognitive decline in Alzheimer’s disease. Psychol Aging 2012; 27: 1008-1017.
23.
Wu W, He X, Xie S, Li B, Chen J, Qu Y, Li B, Lei M, Liu X. Protective effects of Huang-Lian-Jie-Du-Tang against Abeta25-35-induced memory deficits and oxidative stress in rats. J Int Med Res 2020; 48: 300060519893859.
24.
Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Abeta oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res 2014; 264: 173-180.
25.
Zgorzynska E, Dziedzic B, Walczewska A. An overview of the Nrf2/ARE pathway and its role in neurodegenerative diseases. Int J Mol Sci 2021; 22: 9592.
