Levels of selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in patients with hydrocephalus

Kinga Czubowicz; Mariusz Głowacki; Ewa Fersten; Ewa Kozłowska; Robert P. Strosznajder; Zbigniew Czernicki

doi:10.5114/fn.2017.72389

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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4/2017
vol. 55

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abstract:

Original paper

Levels of selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in patients with hydrocephalus

Kinga Czubowicz

,

Mariusz Głowacki

,

Ewa Fersten

,

Ewa Kozłowska

,

Robert P. Strosznajder

,

Zbigniew Czernicki

Folia Neuropathol 2017; 55 (4): 301-307

DOI: https://doi.org/10.5114/fn.2017.72389

Online publish date: 2017/12/29

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Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) absorption and treated by surgical shunt insertion. The early diagnosis of NPH is difficult because of various manifestations of the disease. One of the most promising research directions is biochemical CSF analysis. The aim of this study was to determine the CSF levels of cytokines. The levels of various cytokines (IL-6, IL-8, IL-12, IL-10 and TNF-α) were measured in patients with idiopathic active normal pressure hydrocephalus, arrested hydrocephalus and hydrocephalus with brain atrophy compared to controls. Our study showed that the concentrations of IL-6 and IL-8 were significantly elevated in the group with idiopathic active hydrocephalus compared to control patients. Moreover, we observed that the levels of IL-6 and IL-8 in the group with idiopathic active hydrocephalus were significantly higher compared to patients with arrested hydrocephalus and hydrocephalus with brain atrophy.

keywords:

Levels of selected pro- and anti-inflammatory cytokines in cerebrospinal fluid in patients with hydrocephalus

Kinga Czubowicz , Mariusz Głowacki , Ewa Fersten , Ewa Kozłowska , Robert P. Strosznajder , Zbigniew Czernicki

hydrocephalus, cerebrospinal fluid, cytokines, inflammation

Kinga Czubowicz

,

Mariusz Głowacki

,

Ewa Fersten

,

Ewa Kozłowska

,

Robert P. Strosznajder

,

Zbigniew Czernicki