eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
3/2022
vol. 60
 
Share:
Send email
Share:
abstract:
Original paper

Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p

Qi Zhang
1
,
Wei Shao
2
,
Yanjiang Li
3
,
Lijuan Liu
4
,
Wei Chen
1
,
Chao Wang
1
,
Bingwei Li
1

  1. Department of Neuro-Interventional Surgery, Binzhou Medical University Hospital, Shandong, China
  2. Department of Neurosurgery, Binzhou Medical University Hospital, Shandong, China
  3. Department of Medicine, Binzhou Medical University Hospital, Shandong, China
  4. Anesthesiology Operating Room, Binzhou Medical University Hospital, Shandong, China
Folia Neuropathol 2022; 60 (3): 338-345
DOI: https://doi.org/10.5114/fn.2022.119302
Online publish date: 2022/09/15
View full text Get citation
 
PlumX metrics:
Introduction
Glioma is a collective term for tumors derived from glial cells and neuronal cells in the nervous system, and is the most common malignant tumor in the brain. Nowadays, the problem of poor treatment effect and high recurrence rate of patients remains to be solved.

Material and methods
In this study, the expression levels of LINC01128 in glioma tissues, cells, and normal control group were determined by real-time quantitative PCR (RT-qPCR). Kaplan-Meier curve was used to evaluate the prognosis and survival. Multivariate Cox analysis was chosen to estimate the prognostic risk factors of glioma. Cell counting kit-8 (CCK-8) and Transwell methods were used to detect the effect of silencing LINC01128 on the proliferation, migration, and invasion of glioma cells, and the targeting effect of LINC01128 on miR-27b-3p was determined based on bio-informatics analysis and luciferase activity detection.

Results
LINC01128 was up-regulated in glioma tissues and cells. The possibility of LINC01128 as a prognostic factor of glioma was obtained through Kaplan-Meier’s clinical data analysis and multivariate Cox analysis. Silencing LINC01128 targeting miR-27b-3p inhibited the proliferation, migration, and invasion activity of glioma cells. Moreover, there was a negative correlation between LINC01128 and miR-27b-3p.

Conclusions
Silencing LINC01128 inhibited the proliferation, migration, and invasion levels of glioma cells by targeting miR-27b-3p, thereby affecting the progression of gliomas.

keywords:

glioma, prognosis, lncRNA LINC01128, miR-27b-3p
FEATURED PRODUCTS
BOOKS
• Wprowadzenie do neurologopedii Wydanie II zaktualizowane
EVENTS
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.