eISSN: 2449-9315
ISSN: 1234-8279
Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
2/2020
vol. 36
 
Share:
Share:
abstract:
Review paper

Lurasidone – pharmacodynamic and pharmacokinetic properties, clinical potential and interaction risk

Marcin Siwek
1
,
Anna J. Krupa
2
,
Anna Wasik
1

  1. Zakład Zaburzeń Afektywnych, Katedra Psychiatrii UJCM
  2. Szkoła Doktorska Nauk Medycznych i Nauk o Zdrowiu, UJCM Kraków
Farmakoterapia w Psychiatrii i Neurologii 2020, 36 (2), 117–134
Online publish date: 2021/12/06
View full text Get citation
 
Lurasidone is a novel second-generation antipsychotic approved for the treatment of schizophrenia and bipo lar depression in adults. It displays high affinity for D2 and 5-HT2A and 5-HT7 receptors, moderate affinity for 5-HT1A and α2C-noradrenergic receptors, and negligible affinity for histamine H1 and muscarinic M1 receptors. It acts as potent D2, 5-HT2A and 5-HT7 antagonist and partial 5-HT1A agonist. Lurasidone taken orally is rapidly absorbed with the time to maximum concentration of 1–3 hours. Lurasidone should be taken with food (at least 350 kcal) due to limited absorption. The mean elimination half-life of lurasidone is 18.1–25.5 hours for doses 20–80 mg/day and 28.8–37.4 hours for doses of 120–160 mg/day. Steady-state is reached within 7 days. The drug is metabo lised via CYP3A4 and excreted mainly in faeces (67–80%) and with urine (about 8–19%). The use of lurasidone with strong inhibitors or inducers of CYP3A4 (e.g. ketocona zole, erythromycin, or carbamazepine, respectively) is contraindicated. In the case of combined treatment of lurasidone and moderate inhibitors of CYP3A4, the dose of lurasidone should be decreased to 40 mg/day. Lurasi done is an inhibitor of P-glycoprotein and could increase the level of digoxin and potentate the side effects risk of this drug. Pomelo, grapefruit, or a large amount of orang es should be avoided in the diet during treatment with lurasidone. Pharmacodynamic properties of lurasidone underlie its antipsychotic, antidepressant, precognitive, and sleep-awake rhythm normalising activity.
keywords:

novel antipsychotic, pharmacodynamic properties, pharmacokinetics, interaction risk


Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.