Melodinhenine B attenuates NLRP3 expression in a cerebral ischemia/reperfusion-induced neuronal injury rat model

Wei Li; Huisheng Chen; Zhijia Xu; Yan Lv; Ziai Zhao; Jinghua Zhang; Fang Qu

doi:10.5114/fn.2020.94004

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2020
vol. 58

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abstract:

Original paper

Melodinhenine B attenuates NLRP3 expression in a cerebral ischemia/reperfusion-induced neuronal injury rat model

Wei Li

¹

,

Huisheng Chen

¹

,

Zhijia Xu

¹

,

Yan Lv

¹

,

Ziai Zhao

¹

,

Jinghua Zhang

¹

,

Fang Qu

¹

Department of Neurology, General Hospital of Northern Theater Command, Shenyang, Liaoning, China

Folia Neuropathol 2020; 58 (1): 30-37

DOI: https://doi.org/10.5114/fn.2020.94004

Online publish date: 2020/03/31

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This investigation evaluated the neuroprotective effect of melodinhenine B in a cerebral ischemia/reperfusion (I/R)-induced neuronal injury rat model. The effect of melodinhenine B was determined by evaluating the neurological deficit score, cerebral infarcted area, and blood-brain barrier (BBB) permeability. Moreover, the level of inflammatory cytokines and expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κβ), interleukin-1β (IL-1β), NLRP3, zonula occludens-1 (ZO-1), and occluding proteins were estimated by Western blotting. Histopathological changes and immunohistochemical analysis were performed to estimate the effect of melodinhenine B on neuronal injury. The neurological deficit score, percentage of infarcted area, and BBB permeability were improved in the melodinhenine B-treated group of rats. Treatment with melodinhenine B attenuated the altered expression of NF-κβ, IL-1β, NLRP3, ZO-1, and occluding proteins in the brain tissue of I/R-induced neuronal injury rats. The inflammatory cytokine levels were reduced in the melodinhenine B-treated group. Histopathologically, melodinhenine B reversed the pathological changes in the brain tissues of I/R-induced neuronal injury rats. In conclusion, melodinhenine B protects against neuronal injury in cerebral ischemia-reperfusion injury rats by regulating the inflammasomes.

keywords:

Melodinhenine B attenuates NLRP3 expression in a cerebral ischemia/reperfusion-induced neuronal injury rat model

Wei Li 1 , Huisheng Chen 1 , Zhijia Xu 1 , Yan Lv 1 , Ziai Zhao 1 , Jinghua Zhang 1 , Fang Qu 1

melodinhenine B, neuronal injury, ischemia-reperfusion, inflammasomes

Wei Li

¹

,

Huisheng Chen

¹

,

Zhijia Xu

¹

,

Yan Lv

¹

,

Ziai Zhao

¹

,

Jinghua Zhang

¹

,

Fang Qu

¹