Matrix metalloproteinases in tumor invasion

Joanna Łapińska

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/1999
vol. 3

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abstract:

Matrix metalloproteinases in tumor invasion

Joanna Łapińska

Współcz Onkol (1999) 3, 120-122

Online publish date: 2003/08/05

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One of the processes responsible for tumor cell invasion and metastasis is degradation of the extracellular matrix (ECM) proteins. To overcome the physical barrier, which is ECM, tumor cell produces proteolytic enzymes. A family of metalloproteinases named „matrix metalloproteinases” (MMPs) plays an important role in matrix degradation. Information about MMP and their inhibitors has led to a number of successful inhibitor strategies in tumor treatment.

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Matrix metalloproteinases in tumor invasion

Joanna Łapińska

Matrix metalloproteinases (MMP), tumor invasion